Background Alzheimer's disease (AD) is a neurodegenerative disorder strongly correlated
with a dysfunctional immune system. Our previous results demonstrated that inactivated …

Vaccination remains the most effective prophylactic intervention for infectious disease in the
healthcare professional's toolkit. However, the efficacy and effectiveness of vaccines …

The past two centuries have seen enormous achievements in control of infectious diseases,
previously the leading cause of death, in large measure due to sanitation and food safety …

Progression to severe organ involvement due to dengue infection has been associated with
severe dengue disease, intensive care treatment, and mortality. However, there is a lack of …

Objective This is the first systematic review and meta-analysis to determine the factors that
contribute to poor antibody response in organ transplant recipients after receiving the 2 …

While there is currently no approved norovirus vaccine, recent human clinical efficacy trials
with virus-like particle–based vaccines have shown promise. Several additional norovirus …

Respiratory syncytial virus (RSV) infects elderly (≥ 65 years) adults, causing medically
attended illness and hospitalizations. While RSV neutralizing antibody levels correlate …

A common finding in the elderly population is a chronic subclinical inflammatory status that
coexists with immune dysfunction. These interconnected processes are of sufficient …

All immune cells are affected by aging, contributing to the high susceptibility to infections
and increased mortality observed in the elderly. The effect of aging on cells of the adaptive …

In this article we define vaccinomics as the integration of immunogenetics and
immunogenomics with systems biology and immune profiling. Vaccinomics is based on the …