Vaccinology in the third millennium: scientific and social challenges
GA Poland, JA Whitaker, CM Poland… - Current opinion in …, 2016 - Elsevier
Highlights•Vaccines have eradicated smallpox, nearly eradicated polio, and resulted in
99.9% reduction in incidence rates for many diseases.•There are significant challenges …
99.9% reduction in incidence rates for many diseases.•There are significant challenges …
Human Toll-Like Receptor 8-Selective Agonistic Activities in 1-Alkyl-1H-benzimidazol-2-amines
M Beesu, SS Malladi, LM Fox, CD Jones… - Journal of medicinal …, 2014 - ACS Publications
Toll-like receptor (TLR)-8 agonists strongly induce the production of T helper 1-polarizing
cytokines and may therefore serve as promising candidate vaccine adjuvants, especially for …
cytokines and may therefore serve as promising candidate vaccine adjuvants, especially for …
CD8+ T cell differentiation in the aging immune system: until the last clone standing
VR Buchholz, M Neuenhahn, DH Busch - Current Opinion in Immunology, 2011 - Elsevier
A substantial deterioration of the naïve CD8+ T cell pool occurs regularly in humans beyond
the age of 65 years. While recall responses to pathogens encountered during youth or …
the age of 65 years. While recall responses to pathogens encountered during youth or …
The importance of pertussis in older adults: a growing case for reviewing vaccination strategy in the elderly
I Ridda, JK Yin, C King, CR MacIntyre, P McIntyre - Vaccine, 2012 - Elsevier
Pertussis or whooping cough is increasingly being shown to be a respiratory infection
affecting the elderly and a significant percentage of older people infected with Bordetella …
affecting the elderly and a significant percentage of older people infected with Bordetella …
Pre-treatment with the viral Toll-like receptor 3 agonist poly (I: C) modulates innate immunity and protects neutropenic mice infected intracerebrally with Escherichia …
S Ribes, C Arcilla, M Ott, S Schütze, UK Hanisch… - Journal of …, 2020 - Springer
Background Individuals with impaired immunity are more susceptible to infections than
immunocompetent subjects. No vaccines are currently available to induce protection against …
immunocompetent subjects. No vaccines are currently available to induce protection against …
[HTML][HTML] Three-dose versus four-dose primary schedules for tick-borne encephalitis (TBE) vaccine FSME-immun for those aged 50 years or older: A single-centre …
A Kantele, L Rombo, S Vene, M Kundi, L Lindquist… - Vaccine, 2022 - Elsevier
Background TBE vaccination failures among those past middle age have raised concern
about immune response declining with age. We investigated immunogenicity of the TBE …
about immune response declining with age. We investigated immunogenicity of the TBE …
Persistence of immune response to HPV-16/18 AS04-adjuvanted cervical cancer vaccine in women aged 15-55 years
TF Schwarz, M Spaczynski, A Schneider… - Human …, 2011 - Taylor & Francis
The HPV-16/18 AS04-adjuvanted vaccine (Cervarix®, GlaxoSmithKline Biologicals) has
been shown to induce a robust immune response in women aged 15-55 years (103514 …
been shown to induce a robust immune response in women aged 15-55 years (103514 …
Neutrophils are required during immunization with the pneumococcal conjugate vaccine for protective antibody responses and host defense against infection
EYI Tchalla, M Bhalla, EA Wohlfert… - The Journal of …, 2020 - academic.oup.com
Neutrophils can shape adaptive immunity; however, their role in vaccine-induced protection
against infections in vivo remains unclear. Here, we tested their role in the clinically relevant …
against infections in vivo remains unclear. Here, we tested their role in the clinically relevant …
T cell receptor-mediated activation is a potent inducer of macroautophagy in human CD8+ CD28+ T cells but not in CD8+ CD28− T cells
CR Arnold, T Pritz, S Brunner, C Knabb… - Experimental …, 2014 - Elsevier
A key feature of the aged human immune system is the accumulation of highly differentiated
CD8+ CD28− T cells, a phenomenon that negatively influences immune function in the …
CD8+ CD28− T cells, a phenomenon that negatively influences immune function in the …
A phase I trial using local regional treatment, nonlethal irradiation, intratumoral and systemic polyinosinic-polycytidylic acid polylysine carboxymethylcellulose to treat …
AN de la Torre, S Contractor, I Castaneda… - Journal of …, 2017 - Taylor & Francis
Purpose To determine the safety of an approach to immunologically enhance local treatment
of hepatocellular cancer (HCC) by combining nonlethal radiation, local regional therapy with …
of hepatocellular cancer (HCC) by combining nonlethal radiation, local regional therapy with …