Simple Summary The number of children and adults with cancer that are completely cured is
still increasing thanks to effective anti-cancer therapy, but they may be confronted with the …

DNA is the source of genetic information, and preserving its integrity is essential in order to
sustain life. The genome is continuously threatened by different types of DNA lesions, such …

Cellular senescence is an important factor in aging and many age-related diseases, but
understanding its role in health is challenging due to the lack of exclusive or universal …

The aging of mammals is accompanied by the progressive atrophy of tissues and organs
and the accumulation of random damage to macromolecular DNA, protein, and lipids …

The aging process is a complex biological phenomenon that results in the gradual decline of
physiological function and an increased risk of age-related diseases. While aging is a …

Cancer metabolic reprogramming enhances its malignant behaviors and drug resistance,
which is regulated by POU domain transcription factors. This study explored the effect of …

Inheritance of a BRCA2 pathogenic variant conveys a substantial life-time risk of breast
cancer. Identification of the cell (s)-of-origin of BRCA2-mutant breast cancer and targetable …

Originally identified as an outcome of continuous culture of primary cells, cellular
senescence has moved beyond the culture dish and is now a bona fide driver of aging and …

Increasing evidence demonstrates that DNA damage and genome instability play a crucial
role in ageing. Mammalian cells have developed a wide range of complex and well …

Alzheimer's disease (AD) is the most common type of neurodegenerative disease. Its typical
pathology consists of extracellular amyloid-β (Aβ) plaques and intracellular tau …