Inflammaging and oxidative stress in human diseases: from molecular mechanisms to novel treatments

L Zuo, ER Prather, M Stetskiv, DE Garrison… - International journal of …, 2019 - mdpi.com
It has been proposed that a chronic state of inflammation correlated with aging known as
inflammaging, is implicated in multiple disease states commonly observed in the elderly …

T cell senescence and CAR-T cell exhaustion in hematological malignancies

D Kasakovski, L Xu, Y Li - Journal of hematology & oncology, 2018 - Springer
T cell senescence has been recognized to play an immunosuppressive role in the aging
population and cancer patients. Strategies dedicated to preventing or reversing replicative …

[HTML][HTML] Exercise interventions for older adults: A systematic review of meta-analyses

C Di Lorito, A Long, A Byrne, RH Harwood… - Journal of sport and …, 2021 - Elsevier
Background The evidence concerning which physical exercise characteristics are most
effective for older adults is fragmented. We aimed to characterize the extent of this diversity …

Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema

M Chilosi, A Carloni, A Rossi, V Poletti - Translational Research, 2013 - Elsevier
Different anatomic and physiological changes occur in the lung of aging people that can
affect pulmonary functions, and different pulmonary diseases, including deadly diseases …

Health benefits of aerobic training programs in adults aged 70 and over: a systematic review

W Bouaziz, T Vogel, E Schmitt, G Kaltenbach… - Archives of gerontology …, 2017 - Elsevier
Aging is intrinsically associated with a progressive decline in muscle strength and mass, and
aerobic capacity. This contributes to reduced mobility and impaired quality of life (QoL) …

[HTML][HTML] Immunosenescence in multiple sclerosis: the identification of new therapeutic targets

M Dema, H Eixarch, LM Villar, X Montalban… - Autoimmunity …, 2021 - Elsevier
The number of elderly multiple sclerosis (MS) patients is growing, mainly due to the increase
in the life expectancy of the general population and the availability of effective disease …

Herpes virus in Alzheimer's disease: relation to progression of the disease

I Carbone, T Lazzarotto, M Ianni, E Porcellini, P Forti… - Neurobiology of …, 2014 - Elsevier
Studies regarding different viruses of the herpes family, such as cytomegalovirus (CMV),
Epstein–Barr virus (EBV), or human herpes virus 6 (HHV-6) in Alzheimer's disease (AD) are …

Is immunosenescence influenced by our lifetime “dose” of exercise?

JE Turner - Biogerontology, 2016 - Springer
The age-associated decline in immune function, referred to as immunosenescence, is well
characterised within the adaptive immune system, and in particular, among T cells …

Independent validation of DNA-based approaches for age prediction in blood

S Cho, SE Jung, SR Hong, EH Lee, JH Lee… - Forensic Science …, 2017 - Elsevier
Numerous molecular biomarkers have been proposed as predictors of chronological age.
Among them, T-cell specific DNA rearrangement and DNA methylation markers have been …

Uraemia-induced immune senescence and clinical outcomes in chronic kidney disease patients

T Crépin, M Legendre, C Carron… - Nephrology Dialysis …, 2020 - academic.oup.com
Background Patients with chronic kidney disease (CKD) are more prone to develop
premature age-related diseases. Data on immune senescence are scarce in CKD …