Cancer patients with lymph node (LN) metastases have a worse prognosis than those
without nodal disease. However, why LN metastases correlate with reduced patient survival …

Vessel co-option is a non-angiogenic mechanism of tumour vascularisation in which cancer
cells utilise pre-existing blood vessels instead of inducing new blood vessel formation …

Abstract Background: The anti-angiogenic Sorafenib is the only approved systemic therapy
for advanced hepatocellular carcinoma (HCC). However, acquired resistance limits its …

Lymphatic vessels collect and transport lymph and pathogens to the draining lymph node
(LN) to generate proper immune protection. A layer of macrophages that strategically line …

Purpose Sentinel lymph node biopsy is an essential staging tool in patients with clinically
localized oral cavity squamous cell carcinoma. The harvesting of a sentinel lymph node …

Tumor-draining lymph nodes (TDLNs) are important for tumor antigen–specific T cell
generation and effective anticancer immune responses. However, TDLNs are often the …

Colorectal cancer liver metastasis (CRCLM) has two major histopathological growth
patterns: angiogenic desmoplastic and non-angiogenic replacement. The replacement …

Tumor vessel co-option (VCO) is a non-angiogenic vascularization mechanism that is a
possible cause of resistance to anti-angiogenic therapy (AAT). Multiple tumors are …

Lymph node (LN) metastases correspond with a worse prognosis in nearly all cancers, yet
the occurrence of cancer spreading from LNs remains controversial. Additionally, the …

Hypoxia (low O 2) is a ubiquitous feature of solid cancers, arising as a mismatch between
cellular O 2 supply and consumption. Hypoxia is associated to metastatic disease and …