Our understanding of depression and its treatment has advanced with the advent of
ketamine as a rapid-acting antidepressant and the development and refinement of tools …

The etiology of psychiatric disorders remains largely unknown. The exploration of the
neurobiological mechanisms of mental illness helps improve diagnostic efficacy and …

Dysregulated prefrontal control over amygdala is engaged in the pathogenesis of psychiatric
diseases including depression and anxiety disorders. Here we show that, in a rodent anxiety …

Both the NMDA receptor (NMDAR) positive allosteric modulator (PAM), and antagonist, can
exert rapid antidepressant effects as shown in several animal and human studies. However …

Opioid-based drugs are frequently used for pain management in both males and females
despite the known risk of prefrontal cortex dysfunction and cognitive impairments. Although …

Ghrelin receptor, also known as growth hormone secretagogue receptor (GHS-R1a), is
coexpressed with its truncated isoform GHS-R1b, which does not bind ghrelin or signal, but …

Astrocytes are integral components of synaptic transmission, and their dysfunction leads to
neuropsychiatric disorders such as anxiety and depression. Liver X receptor β (LXRβ) is …

Early life adversity in humans is linked to cognitive deficits and increased risk of mental
illnesses, including depression, bipolar disorder, and schizophrenia, with evidence for …

Background Chronic stress exposure increases the risk of mental health problems such as
anxiety and depression. The medial prefrontal cortex (mPFC) is a hub for controlling stress …

Major depressive disorder (MDD) remains one of the leading causes of disability and
functional impairment worldwide. Current antidepressant therapeutics require weeks to …