Abstract Background The BNT162b2 mRNA vaccine has been shown to be effective at
preventing serious COVID-19 events in clinical trials. There is less evidence on …

Introduction Randomized-controlled trials of mRNA vaccine protection against SARS-CoV-2
included relatively few elderly participants. We assess singe-dose mRNA vaccine …

Alzheimer's disease (AD) constitutes a major cause of dementia, affecting more women than
men. It is characterized by amyloid-β (Aβ) deposition and neurofibrillary tangles (NFTs) …

Background Immune responses to COVID-19 mRNA vaccines have not been well
characterized in frail older adults. We postulated that frailty is associated with impaired …

Aging-associated remodeling of the immune system impairs its functional integrity and
contributes to increased morbidity and mortality in the elderly. Aging of hematopoietic stem …

The BM is well understood to play a key role in plasma cell homing and survival in mice. In
humans, BM plasma cells and their functions are less well characterized. In this study, we …

Abstract Purpose of the Review Aging clearly impacts a wide array of systems, in particular
the breadth of the immune system leading to immunosenescence, altered immunoactivation …

The bone marrow (BM) plays a key role in the long‐term maintenance of immunological
memory. However, the impact of aging on the production of survival factors for …

The immune system of the elderly is particularly susceptible to infectious diseases and
displays reduced response to vaccination. The current vaccines, designed for young and …

MicroRNAs have emerged as key regulators in T cell development, activation, and
differentiation, with miR-181a having a prominent function. By targeting several signaling …