Profiling immunologic risk for acute rejection in liver transplantation: recipient age is an important risk factor

ML Kueht, RT Cotton, NTN Galvan, CA O'Mahony… - Transplant …, 2016 - Elsevier
Background Careful management of induction and maintenance of immunosuppression is
paramount to prevent acute rejection in liver transplantation. A methodical analysis of risk …

[HTML][HTML] Clinical and kinomic analysis identifies peripheral blood mononuclear cells as a potential pharmacodynamic biomarker in metastatic renal cell carcinoma …

G Noé, A Bellesoeur, A Thomas-Schoemann… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Background Sunitinib is a protein tyrosine kinase (PTK) inhibitor that has immune-
modulating properties. In this context, peripheral blood mononuclear cells (PBMC), mainly …

CpG improves influenza vaccine efficacy in young adult but not aged mice

A Ramirez, M Co, A Mathew - PLoS One, 2016 - journals.plos.org
Several studies have shown a reduced efficacy of influenza vaccines in the elderly
compared to young adults. In this study, we evaluated the immunogenicity and protective …

[HTML][HTML] Frailty and age impact immune responses to moderna COVID-19 mRNA vaccine

CT Semelka, ME DeWitt, MW Blevins… - Research …, 2022 - ncbi.nlm.nih.gov
BACKGROUND: Immune responses to COVID-19 mRNA vaccines have not been well
characterized in frail older adults. We postulated that frailty is associated with impaired …

[HTML][HTML] Immunomodulatory Effects of modified Colostrum, Whey, and their combination with other natural products: Effects on Natural Killer Cells

X Han, D Vollmer, X Yan, Y Zhang, M Zang… - Current Therapeutic …, 2024 - Elsevier
Objectives: Natural killer (NK) cells are important immune system effector cells providing
innate defenses against intracellular infections, including viral infections, immune …

Novel intervention in the aging population: a primary meningococcal vaccine inducing protective IgM responses in middle-aged adults

M van der Heiden, AMH Boots… - Frontiers in …, 2017 - frontiersin.org
Introduction Vaccine responses are often reduced in the elderly, leaving part of the elderly
population vulnerable to infectious diseases. Timely vaccination may offer a solution for …

Interaction of engineered nanomaterials with the immune system: health-related safety and possible benefits

D Boraschi, BJ Swartzwelter, P Italiani - Current Opinion in Toxicology, 2018 - Elsevier
Understanding the mechanisms of interaction between nanomaterials and the immune
system will provide us with endless possibilities of exploiting nano-objects for tuning …

Monophosphoryl Lipid A–based Adjuvant to Promote the Immunogenicity of Multivalent Meningococcal Polysaccharide Conjugate Vaccines

KR Alugupalli - ImmunoHorizons, 2024 - journals.aai.org
Activation of the adaptive immune system requires the engagement of costimulatory
pathways in addition to B and T cell Ag receptor signaling, and adjuvants play a central role …

Gambaran Penyakit Komorbid pada Lansia yang dirawat dengan Covid-19 di Rs Bhayangkara Pekanbaru

ER Naya, D Kurniawan, M Rustam - Jurnal Vokasi Keperawatan …, 2022 - ejournal.unib.ac.id
METODEr Penelitianrini adalah penelitian kuantitatif dengan survei analitik yang
menggunakan pendekatan retrospective study. Variabel dalam penelitian ini adalah …

Intrinsic defects in lymph node stromal cells underpin poor germinal center responses during aging

AE Denton, A Silva-Cayetano, J Dooley, DL Hill… - BioRxiv, 2020 - biorxiv.org
The failure to generate enduring humoral immunity after vaccination is a hallmark of
advancing age. This can be attributed in part to a reduction in the germinal center response …