Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Exosomal circRNA serves a novel genetic information molecule, facilitating communication
between tumor cells and microenvironmental cells, such as immune cells, fibroblasts, and …

Cancer is the main cause of death worldwide and metastasis is a major cause of poor
prognosis and cancer-associated mortality. Metastatic conversion of cancer cells is a …

Cancer-associated fibroblasts (CAFs) exhibit considerable heterogeneity in advanced
cancers; however, the functional annotation and mechanism of CAFs in early-stage cancers …

Emerging evidence has demonstrated that circular RNAs (circRNA) are involved in cancer
metastasis. Further elucidation of the role of circRNAs in oral squamous cell carcinoma …

Although cancer immunotherapy is a compelling approach against cancer, its effectiveness
is hindered by the challenge of generating a robust and durable immune response against …

The characteristics of the tumour cells, as well as how tumour cells interact with their
surroundings, affect the prognosis of cancer patients. The resident cells in the tumour …

Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …

Lymphangiogenesis refers to the generation of new lymphatic vessels from pre-existing
ones. During development and particular adult states, lymphatic endothelial cells (LEC) …