Abstract Niemann-Pick type C (NPC) disease is a lysosomal storage disease (LSD)
characterized by the buildup of endo-lysosomal cholesterol and glycosphingolipids due to …

Major depressive disorder (MDD) is a common psychiatric illness with a wide range of
symptoms such as mood decline, loss of interest, and feelings of guilt and worthlessness …

Aberrant microstructure of the uncinate fasciculus (UNC), a white matter (WM) tract
implicated in emotion regulation, has been hypothesized as a neurobiological mechanism of …

Importance Adolescent major depressive disorder (MDD) is associated with serious adverse
implications for brain development and higher rates of self-injury and suicide, raising …

Adolescent depression is characterized by heightened inflammation and altered connectivity
of fronto-cingulate-limbic tracts, including the genu of the corpus callosum (CCG) and the …

Ca2+ signaling is essential for oligodendrocyte (OL) development and myelin formation.
Inositol 1, 4, 5‐trisphosphate receptor type 2 (ITPR2) is an endoplasmic reticulum calcium …

Evidence for myelin regulating higher‐order brain function and disease is rapidly
accumulating; however, defining cellular/molecular mechanisms remains challenging …

Adolescence, the transition between childhood and adulthood, is characterized by rapid
brain development in white matter (WM) that is attributed in part to rising levels in adrenal …

Introduction: Compared to research on adults with depression, relatively little work has
examined white matter microstructure differences in depression arising earlier in life. Here …

Background Neighborhood-or area-level socioeconomic disadvantage is associated with
neural alterations across the life span. However, few studies have examined the effects of …