“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …

Human aging is characterized by both physical and physiological frailty that profoundly
affects the immune system. In this context aging is associated with declines in adaptive and …

Senescent cells are generally characterized by permanent cell cycle arrest, metabolic
alteration and activation, and apoptotic resistance in multiple organs due to various …

Background Older adults at a higher risk of adverse outcomes and mortality if they get
infected with Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These …

Introduction Ageing is associated with several physiological changes, including changes in
the immune system. Age-related changes in the innate and adaptive immune system are …

Background Immune responses to COVID-19 mRNA vaccines have not been well
characterized in frail older adults. We postulated that frailty is associated with impaired …

Background Besides physical activity as a target for dementia prevention, sedentary
behaviour is hypothesized to be a potential target in its own right. The rising number of …

Aging is often associated with a loss of function. We believe aging to be more an adaptation
to the various, and often continuous, stressors encountered during life in order to maintain …

Neutrophil dysfunction has been described with age, appears exaggerated in infection, with
altered phosphoinositol signaling a potential mechanism. However, functional aging is …

Background The effects of fasting on health in non-human models have been widely
publicised for a long time and emerging evidence support the idea that these effects can be …