[HTML][HTML] Congenital aniridia beyond black eyes: from phenotype and novel genetic mechanisms to innovative therapeutic approaches
Congenital PAX6-aniridia, initially characterized by the absence of the iris, has progressively
been shown to be associated with other developmental ocular abnormalities and systemic …
been shown to be associated with other developmental ocular abnormalities and systemic …
Modeling post-implantation stages of human development into early organogenesis with stem-cell-derived peri-gastruloids
In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …
[HTML][HTML] Report on the 2021 Aniridia North America symposium on PAX6, aniridia, and beyond
Abstract The inaugural Aniridia North America (ANA) Symposium was held on the first
weekend in November 2021 in Charlottesville, VA, at the University of Virginia. The purpose …
weekend in November 2021 in Charlottesville, VA, at the University of Virginia. The purpose …
One-stop assembly of adherent 3D retinal organoids from hiPSCs based on 3D-printed derived PDMS microwell platform
Abstract The three-dimensional (3D) retinal organoids (ROs) derived from human induced
pluripotent stem cells (hiPSCs), mimicking the growth and development of the human retina …
pluripotent stem cells (hiPSCs), mimicking the growth and development of the human retina …
NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal development
While dysfunction and death of light-detecting photoreceptor cells underlie most inherited
retinal dystrophies, knowledge of the species-specific details of human rod and cone …
retinal dystrophies, knowledge of the species-specific details of human rod and cone …
Dynamic changes in whole genome DNA methylation, chromatin and gene expression during mouse lens differentiation
Background Cellular differentiation is marked by temporally and spatially coordinated gene
expression regulated at multiple levels. DNA methylation represents a universal mechanism …
expression regulated at multiple levels. DNA methylation represents a universal mechanism …
Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis
Mammalian retinal metabolism favors aerobic glycolysis. However, the role of glycolytic
metabolism in retinal morphogenesis remains unknown. We report that aerobic glycolysis is …
metabolism in retinal morphogenesis remains unknown. We report that aerobic glycolysis is …
Generation of lens progenitor cells and lentoid bodies from pluripotent stem cells: Novel tools for human lens development and ocular disease etiology
A Cvekl, MJ Camerino - Cells, 2022 - mdpi.com
In vitro differentiation of human pluripotent stem cells (hPSCs) into specialized tissues and
organs represents a powerful approach to gain insight into those cellular and molecular …
organs represents a powerful approach to gain insight into those cellular and molecular …
Roles of histone acetyltransferases and deacetylases in the retinal development and diseases
J Wang, S Feng, Q Zhang, H Qin, C Xu, X Fu… - Molecular …, 2023 - Springer
The critical role of epigenetic modification of histones in maintaining the normal function of
the nervous system has attracted increasing attention. Among these modifications, the level …
the nervous system has attracted increasing attention. Among these modifications, the level …
Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells
S Jung, SH Ko, N Ahn, J Lee, CH Park… - Nature …, 2024 - nature.com
Abstract UPF1 and LIN28A are RNA-binding proteins involved in post-transcriptional
regulation and stem cell differentiation. Most studies on UPF1 and LIN28A have focused on …
regulation and stem cell differentiation. Most studies on UPF1 and LIN28A have focused on …