生长因子是一类由多种细胞分泌的活性物质, 作为信使调控细胞的迁移, 增殖和分化.
多种生长因子参与眼组织的发育及眼部疾病的生理, 病理过程. 血管内皮生长因子 …

Human induced pluripotent stem cells (hiPSCs) hold considerable promise for autologous
cellular therapies, particularly in ocular disease treatment, because of the low numbers of …

Formation, maintenance, and differentiation of tissue-specific progenitor cells are
fundamental tasks during organogenesis. Retinal development is an excellent model for …

Human retinal stem cells hold great promise in regenerative medicine, yet their existence
and characteristics remain elusive. Here, we preformed single-cell multi-omics and spatial …

Gene amplifications, or additional copies of a specific gene or genomic region, are known to
occur in cancer cells and to be linked to worse prognosis, probably by aiding them to resist …

How neurons wire together to form circuits is a central pillar of our mental abilities and often
leads to disease when gone awry. This fact highlights the importance of neurons correctly …

Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer. It can be
classified into T and B cell lineage leukemias, with B-ALL being more common, and …

Sight relies on the integrity of the photoreceptor cells of the retina (rods and cones), and
damage to these cells results in irreversible vision loss. Several degenerative diseases …

Purpose Loss of function of heat shock factor 4 (HSF4) causes microphthalmia with lens
opacification. The objective of this study is to uncover the regulation of HSF4 on retinal …

Aniridia is a rare congenital blindness caused by heterozygous variants in the PAX6 gene.
There is no vision-saving therapy, but one exciting approach is the gene editing capabilities …