Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in
response to cellular damage and stress. Senescent cells (SnCs) can develop a …

Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

Ageing of the immune system, or immunosenescence, contributes to the morbidity and
mortality of the elderly,. To define the contribution of immune system ageing to organism …

Cellular senescence is a permanent state of cell cycle arrest that occurs in proliferating cells
subjected to different stresses. Senescence is, therefore, a cellular defense mechanism that …

Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the
tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here …

Senescent cells (SnCs) are implicated in the pathogenesis of age-related diseases
including osteoarthritis (OA), in part via expression of a senescence-associated secretory …

The activation of cellular senescence throughout the lifespan promotes tumor suppression,
whereas the persistence of senescent cells contributes to aspects of aging. This theory has …

Changes in aging bone that lead to osteoporosis are mediated at multiple levels, including
hormonal alterations, skeletal unloading, and accumulation of senescent cells. This …

The immune system is the central regulator of tissue homeostasis, ensuring tissue
regeneration and protection against both pathogens and the neoformation of cancer cells. Its …

Knowledge of aging biology needs to be expanded due to the continuously growing number
of elderly people worldwide. Aging induces changes that affect all systems of the body. The …