[PDF][PDF] The world goes bats: living longer and tolerating viruses
For centuries, people believed that bats possessed sinister powers. Bats are thought to be
ancestral hosts to many deadly viruses affecting humans including Ebola, rabies, and most …
ancestral hosts to many deadly viruses affecting humans including Ebola, rabies, and most …
[HTML][HTML] Alternative animal models of aging research
S Holtze, E Gorshkova, S Braude… - Frontiers in Molecular …, 2021 - frontiersin.org
Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …
Six reference-quality genomes reveal evolution of bat adaptations
Bats possess extraordinary adaptations, including flight, echolocation, extreme longevity
and unique immunity. High-quality genomes are crucial for understanding the molecular …
and unique immunity. High-quality genomes are crucial for understanding the molecular …
[PDF][PDF] Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation
Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative
transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with …
transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with …
Recurrent evolution of vertebrate transcription factors by transposase capture
RL Cosby, J Judd, R Zhang, A Zhong, N Garry… - Science, 2021 - science.org
INTRODUCTION How novel protein architectures evolve remains poorly understood. The
rearrangement of domains with preexisting functions into new composite architectures …
rearrangement of domains with preexisting functions into new composite architectures …
Post COVID‐19: a solution scan of options for preventing future zoonotic epidemics
The crisis generated by the emergence and pandemic spread of COVID‐19 has thrown into
the global spotlight the dangers associated with novel diseases, as well as the key role of …
the global spotlight the dangers associated with novel diseases, as well as the key role of …
[PDF][PDF] Strategies to prevent or remediate cancer and treatment-related aging
JL Guida, T Agurs-Collins, TA Ahles… - JNCI: Journal of the …, 2021 - academic.oup.com
Up to 85% of adult cancer survivors and 99% of adult survivors of childhood cancer live with
an accumulation of chronic conditions, frailty, and/or cognitive impairments resulting from …
an accumulation of chronic conditions, frailty, and/or cognitive impairments resulting from …
[PDF][PDF] Bat pluripotent stem cells reveal unusual entanglement between host and viruses
Bats are distinctive among mammals due to their ability to fly, use laryngeal echolocation,
and tolerate viruses. However, there are currently no reliable cellular models for studying bat …
and tolerate viruses. However, there are currently no reliable cellular models for studying bat …
Chiropterans are a hotspot for horizontal transfer of DNA transposons in Mammalia
Horizontal transfer of transposable elements (TEs) is an important mechanism contributing
to genetic diversity and innovation. Bats (order Chiroptera) have repeatedly been shown to …
to genetic diversity and innovation. Bats (order Chiroptera) have repeatedly been shown to …
Large‐scale across species transcriptomic analysis identifies genetic selection signatures associated with longevity in mammals
Lifespan varies significantly among mammals, with more than 100‐fold difference between
the shortest and longest living species. This natural difference may uncover the evolutionary …
the shortest and longest living species. This natural difference may uncover the evolutionary …