Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …

Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

Background Given associations linking early life adversity, pubertal timing, and biological
aging, we examined the direct and indirect effects of early life trauma on adult biological …

Recent studies have demonstrated that the DNA methylome changes with age. This
epigenetic drift may have deep implications for cellular differentiation and disease …

Research examining the association between exposure to a wide range of adverse
childhood experiences (ACEs) and accelerated biological aging in older adults is limited …

The progression of this work to human trials was historically delayed by the misconception
that interventions originally identified to extend rodent lifespan lacked a feasible translation …

Background There is evidence that complex diseases and mortality are associated with DNA
methylation (DNAm) and age acceleration. Numerous epigenetic clocks, including Horvath …

Epigenetic age (EA) is an emerging DNA methylation-based biomarker of biological aging,
but whether EA is causally associated with short-term PM2. 5 exposure remains unknown …

The naked mole-rat, Heterocephalus glaber (NMR), the longest-lived rodent, is of
significance and interest in the study of biomarkers for ageing. Recent breakthroughs in this …