IgG4 is the least abundant subclass of IgG in human serum and has unique functional
features. IgG4 is largely unable to activate antibody-dependent immune effector responses …

Objective To review the different causes of secondary immunodeficiencies and provide
clinicians with an updated overview of potential factors that contribute to immunodeficiency …

Despite their crucial role in health and disease, our knowledge of immune cells within
human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 …

High-level expression of the transcription factor T-bet characterizes a phenotypically distinct
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …

Immune effector cell (IEC) therapies offer durable and sustained remissions in significant
numbers of patients with hematological cancers. While these unique immunotherapies have …

Studies on the interactions between SARS‐CoV‐2 and humoral immunity are fundamental
to elaborate effective therapies including vaccines. We used polychromatic flow cytometry …

Impaired humoral responses, as well as an increased propensity for autoimmunity, play an
important role in the development of immune system dysfunction associated with aging …

Spaceflight and its associated stressors, such as microgravity, radiation exposure,
confinement, circadian derailment and disruptive workloads represent an unprecedented …

Vaccines are a highly effective intervention for conferring protection against infections and
reducing the associated morbidity and mortality in vaccinated individuals. However, ageing …

Analysis of autoinflammatory and immunodeficiency disorders elucidates human immunity
and fosters the development of targeted therapies. Oligoadenylate synthetase 1 is a type I …