Approach to COVID-19 in older adults and indications for improving the outcomes

C Tana, L Moffa, K Falasca, J Vecchiet, M Tana… - Annals of …, 2023 - Taylor & Francis
Background: COVID-19 continues to present challenges in the care of older adults with
frailty and/or comorbidities and very old patients, who can be hospitalized with severe …

Comparative risks of potential adverse events following COVID-19 mRNA vaccination among older US adults

DA Harris, KN Hayes, AR Zullo, V Mor… - JAMA Network …, 2023 - jamanetwork.com
Importance Head-to-head safety comparisons of the mRNA vaccines for SARS-CoV-2 are
needed for decision making; however, current evidence generalizes poorly to older adults …

Impact of integrated health care on elderly population: A systematic review of Taiwan's experience

TL Chen, YH Feng, SL Kao, JW Lu, CH Loh - Archives of gerontology and …, 2022 - Elsevier
Background Care fragmentation in the elderly population prompted the need for integrated
health care systems. However, evidence regarding the impact of the integrated care system …

Factors influencing estimated effectiveness of COVID-19 vaccines in non-randomised studies

JPA Ioannidis - BMJ Evidence-Based Medicine, 2022 - ebm.bmj.com
Non-randomised studies assessing COVID-19 vaccine effectiveness need to consider
multiple factors that may generate spurious estimates due to bias or genuinely modify …

Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults

CT Semelka, ME DeWitt, MW Blevins, BC Holbrook… - Immunity & …, 2023 - Springer
Background Immune responses to COVID-19 mRNA vaccines have not been well
characterized in frail older adults. We postulated that frailty is associated with impaired …

Two Years with COVID-19: The Electronic Frailty Index Identifies High-Risk Patients in the Stockholm GeroCovid Study

JKL Mak, M Eriksdotter, M Annetorp, R Kuja-Halkola… - Gerontology, 2023 - karger.com
Introduction: Frailty, a measure of biological aging, has been linked to worse COVID-19
outcomes. However, as the mortality differs across the COVID-19 waves, it is less clear …

Antibody responses to COVID‐19 vaccines in older adults

R Bag Soytas, M Cengiz, MS Islamoglu… - Journal of Medical …, 2022 - Wiley Online Library
Because of the senescence of the immune system, antibody response to the COVID‐19
vaccines may differ from older to younger adults. The study aim compares the titers of SARS …

Clinical features of SARS-CoV-2 infection in older adults

F Remelli, S Volpato… - Clinics in geriatric …, 2022 - geriatric.theclinics.com
In April 2020, the SARS-CoV-2 (COVID-19) infection was declared a pandemic emergency
by the World Health Organization, 1 and after 2 years, in January 2022, the virus had …

A multidimensional approach to older patients during COVID-19 pandemic: a position paper of the special interest group on comprehensive geriatric assessment of …

A Pilotto, C Custodero, K Palmer… - European Geriatric …, 2023 - Springer
Purpose The COVID-19 pandemic has been a dramatic trigger that has challenged the
intrinsic capacity of older adults and of society. Due to the consequences for the older …

[HTML][HTML] Frailty and age impact immune responses to moderna COVID-19 mRNA vaccine

CT Semelka, ME DeWitt, MW Blevins… - Research …, 2022 - ncbi.nlm.nih.gov
BACKGROUND: Immune responses to COVID-19 mRNA vaccines have not been well
characterized in frail older adults. We postulated that frailty is associated with impaired …