Aging and respiratory viral infection: from acute morbidity to chronic sequelae
The altered immune response in aged hosts play a vital role in contributing to their
increased morbidity and mortality during respiratory virus infections. The aged hosts display …
increased morbidity and mortality during respiratory virus infections. The aged hosts display …
The preventive strategy for pandemics in the elderly is to collect in advance samples & data to counteract chronic inflammation (inflammaging)
Fighting the current COVID-19 pandemic, we must not forget to prepare for the next. Since
elderly and frail people are at high risk, we wish to predict their vulnerability, and intervene if …
elderly and frail people are at high risk, we wish to predict their vulnerability, and intervene if …
“Reframing” dopamine signaling at the intersection of glial networks in the aged Parkinsonian brain as innate Nrf2/Wnt driver: Therapeutical implications
B Marchetti, C Giachino, C Tirolo, MF Serapide - Aging Cell, 2022 - Wiley Online Library
Dopamine (DA) signaling via G protein‐coupled receptors is a multifunctional
neurotransmitter and neuroendocrine–immune modulator. The DA nigrostriatal pathway …
neurotransmitter and neuroendocrine–immune modulator. The DA nigrostriatal pathway …
Antibody and transcription landscape in peripheral blood mononuclear cells of elderly adults over 70 years of age with third dose of COVID-19 BBIBP-CorV and …
Y Zhang, L Zhao, J Zhang, X Zhang, S Han, Q Sun… - Immunity & …, 2024 - Springer
Background In the context of the COVID-19 pandemic and extensive vaccination, it is
important to explore the immune response of elderly adults to homologous and …
important to explore the immune response of elderly adults to homologous and …
Recovery of new-onset kidney disease in COVID-19 patients discharged from hospital
NH Zhang, YC Cheng, R Luo, CX Zhang, SW Ge… - BMC infectious …, 2021 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) has emerged as a major global
health threat with a great number of deaths worldwide. Despite abundant data on that many …
health threat with a great number of deaths worldwide. Despite abundant data on that many …
[HTML][HTML] COVID-19 mortality rate in children is U-shaped
N Khera, D Santesmasses, C Kerepesi… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Children are known to be better protected from COVID-19 than adults, but their susceptibility
patterns and the risk relative to other diseases are insufficiently defined. Here, we found that …
patterns and the risk relative to other diseases are insufficiently defined. Here, we found that …
COVID-19: a challenge to physiology of aging
AG Golubev - Frontiers in physiology, 2020 - frontiersin.org
The death toll of the current COVID-19 pandemic is strongly biased toward the elderly.
COVID-19 case fatality rate (CFR) increases with age exponentially, its doubling time being …
COVID-19 case fatality rate (CFR) increases with age exponentially, its doubling time being …
Immune age and biological age as determinants of vaccine responsiveness among elderly populations: The Human Immunomics Initiative research program
J Goudsmit, AHJ van den Biggelaar… - European Journal of …, 2021 - Springer
Abstract The Human Immunomics Initiative (HII), a joint project between the Harvard TH
Chan School of Public Health and the Human Vaccines Project (HVP), focuses on studying …
Chan School of Public Health and the Human Vaccines Project (HVP), focuses on studying …
Importance of population-based longitudinal studies to understanding the impact of COVID-19
P Demakakos - J Epidemiol Community Health, 2021 - jech.bmj.com
High-quality population-based surveillance studies such as the COVID-19 Infection Survey
and Real-time Assessment of Community Transmission Study primarily serve the purpose of …
and Real-time Assessment of Community Transmission Study primarily serve the purpose of …
Telomere length and COVID-19 outcomes: a two-sample bidirectional mendelian randomization study
L Jiang, B Tang, J Guo, J Li - Frontiers in Genetics, 2022 - frontiersin.org
Observational studies have found a relationship between directly measured short leukocyte
telomere length (LTL) and severe coronavirus disease 19 (COVID-19). We investigated the …
telomere length (LTL) and severe coronavirus disease 19 (COVID-19). We investigated the …