Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

The traditional view of chronic obstructive pulmonary disease (COPD) as a self-inflicted
disease caused by tobacco smoking in genetically susceptible individuals has been …

Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …

Different psychiatric disorders as well as exposure to adverse life events have individually
been associated with multiple age-related diseases and mortality. Age acceleration in …

A central prediction of evolutionary theory is that energy invested into reproduction comes at
the expense of somatic maintenance and repair, accelerating biological aging. Supporting …

The prevalence of obesity has dramatically increased worldwide over the past decades.
Aging-related chronic conditions, such as type 2 diabetes and cardiovascular disease, are …

Recent studies demonstrating epigenetic and developmental sensitivity to early
environments, as exemplified by fields like the Developmental Origins of Health and …

Motivated by our conduct of a literature review on social exposures and accelerated aging
as measured by a growing number of epigenetic “clocks”(which estimate age via DNA …

Females live longer than males, and there are sex disparities in physical health and disease
incidence. However, sex differences in biological aging have not been consistently reported …

To build health equity for an aging world marked by dramatic disparities in healthy lifespan
between countries, regions and population groups, research at the intersections of biology …