Measuring biological age using omics data

J Rutledge, H Oh, T Wyss-Coray - Nature Reviews Genetics, 2022 - nature.com
Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

From discoveries in ageing research to therapeutics for healthy ageing

J Campisi, P Kapahi, GJ Lithgow, S Melov, JC Newman… - Nature, 2019 - nature.com
For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …

Measuring biological aging in humans: A quest

L Ferrucci, M Gonzalez‐Freire, E Fabbri… - Aging cell, 2020 - Wiley Online Library
The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

Hallmarks of senescence and aging

S Dodig, I Čepelak, I Pavić - Biochemia medica, 2019 - hrcak.srce.hr
Sažetak The complex process of biological aging, as an intrinsic feature of living beings, is
the result of genetic and, to a greater extent, environmental factors and time. For many of the …

Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up

X Li, A Ploner, Y Wang, PKE Magnusson, C Reynolds… - Elife, 2020 - elifesciences.org
Biological age measurements (BAs) assess aging-related physiological change and predict
health risks among individuals of the same chronological age (CA). Multiple BAs have been …

Brain age and other bodily 'ages': implications for neuropsychiatry

JH Cole, RE Marioni, SE Harris, IJ Deary - Molecular psychiatry, 2019 - nature.com
As our brains age, we tend to experience cognitive decline and are at greater risk of
neurodegenerative disease and dementia. Symptoms of chronic neuropsychiatric diseases …

The accelerated aging phenotype: the role of race and social determinants of health on aging

NN Hooten, NL Pacheco, JT Smith, MK Evans - Ageing Research Reviews, 2022 - Elsevier
The pursuit to discover the fundamental biology and mechanisms of aging within the context
of the physical and social environment is critical to designing interventions to prevent and …

Cancer and aging: two tightly interconnected biological processes

L Berben, G Floris, H Wildiers, S Hatse - Cancers, 2021 - mdpi.com
Simple Summary As life expectancy is increasing, the older population is rapidly growing.
However, older patients with cancer are still underrepresented in clinical trials, making …

The role of lipid metabolism in aging, lifespan regulation, and age‐related disease

AA Johnson, A Stolzing - Aging cell, 2019 - Wiley Online Library
An emerging body of data suggests that lipid metabolism has an important role to play in the
aging process. Indeed, a plethora of dietary, pharmacological, genetic, and surgical lipid …

The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis

PD Fransquet, J Wrigglesworth, RL Woods, ME Ernst… - Clinical …, 2019 - Springer
Background Ageing is one of the principal risk factors for many chronic diseases. However,
there is considerable between-person variation in the rate of ageing and individual …