Biomarkers of aging for the identification and evaluation of longevity interventions

M Moqri, C Herzog, JR Poganik, J Justice, DW Belsky… - Cell, 2023 - cell.com
With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …

A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup

JN Justice, L Ferrucci, AB Newman, VR Aroda… - Geroscience, 2018 - Springer
Recent advances indicate that biological aging is a potentially modifiable driver of late-life
function and chronic disease and have led to the development of geroscience-guided …

[HTML][HTML] Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities

F Galkin, P Mamoshina, A Aliper… - Ageing Research …, 2020 - Elsevier
The aging process results in multiple traceable footprints, which can be quantified and used
to estimate an organism's age. Examples of such aging biomarkers include epigenetic …

Determining a multimodal aging clock in a cohort of Chinese women

J Li, M Xiong, XH Fu, Y Fan, C Dong, X Sun, F Zheng… - Med, 2023 - cell.com
Background Translating aging rejuvenation strategies into clinical practice has the potential
to address the unmet needs of the global aging population. However, to successfully do so …

Curcumin as prospective anti-aging natural compound: focus on brain

T Benameur, R Soleti, MA Panaro, ME La Torre… - Molecules, 2021 - mdpi.com
The nutrients and their potential benefits are a new field of study in modern medicine for
their positive impact on health. Curcumin, the yellow polyphenolic compound extracted from …

Association of unhealthy lifestyle and childhood adversity with acceleration of aging among UK biobank participants

G Yang, X Cao, X Li, J Zhang, C Ma, N Zhang… - JAMA network …, 2022 - jamanetwork.com
Importance Accelerated aging makes adults more vulnerable to chronic diseases and death.
Whether childhood adversity is associated with accelerated aging processes, and to what …

The untwining of immunosenescence and aging

W Xu, G Wong, YY Hwang, A Larbi - Seminars in immunopathology, 2020 - Springer
From a holistic point of view, aging results from the cumulative erosion of the various
systems. Among these, the immune system is interconnected to the rest as immune cells are …

Telomere length: how the length makes a difference

M Lulkiewicz, J Bajsert, P Kopczynski… - Molecular Biology …, 2020 - Springer
Telomerase is perceived as an immortality enzyme that might provide longevity to cells and
whole organisms. Importantly, it is generally inactive in most somatic cells of healthy, adult …

[HTML][HTML] Personal airborne chemical exposure and epigenetic ageing biomarkers in healthy Chinese elderly individuals: evidence from mixture approaches

W Shi, X Gao, Y Cao, Y Chen, Q Cui, F Deng… - Environment …, 2022 - Elsevier
Background Air pollution is associated with accelerated biological ages determined by DNA
methylation (DNAm) patterns, imposing further risks of age-related adverse effects …

Ranking biomarkers of aging by citation profiling and effort scoring

A Hartmann, C Hartmann, R Secci, A Hermann… - Frontiers in …, 2021 - frontiersin.org
Aging affects most living organisms and includes the processes that reduce health and
survival. The chronological and the biological age of individuals can differ remarkably, and …