The shift of the paradigm between ageing and diseases

F Salvatore - Clinical Chemistry and Laboratory Medicine (CCLM), 2020 - degruyter.com
In the area of the Medical Sciences, the chronological age has always been, and still is, an
indicator by which we try to understand the health status of an individual. However, besides …

Environment, Epigenetics, and the Pace of Human Aging

EA Goldman, KN Sterner - Annual Review of Anthropology, 2023 - annualreviews.org
The trajectory of human aging varies widely from one individual to the next due to complex
interactions between the genome and the environment that influence the aging process …

Key molecular mechanisms of aging, biomarkers, and potential interventions

EN Proshkina, IA Solovev, MV Shaposhnikov… - Molecular biology, 2020 - Springer
The mechanisms of aging are described at the molecular, cell, tissue, and systemic levels.
Primary age-dependent molecular lesions activate the cell stress response to compensate …

Evaluation of different computational methods for DNA methylation-based biological age

P Di Lena, C Sala, C Nardini - Briefings in Bioinformatics, 2022 - academic.oup.com
In recent years there has been a widespread interest in researching biomarkers of aging that
could predict physiological vulnerability better than chronological age. Aging, in fact, is one …

[HTML][HTML] Network of biomarkers and their mediation effects on the associations between regular exercise and the incidence of cardiovascular & metabolic diseases

JY Park, J Choi, JE Kim, M Lee, A Shin, J Lee… - Scientific Reports, 2021 - nature.com
This study aimed to understand the biological process related to the prevention of
cardiovascular & metabolic diseases (CMD), including diabetes, hypertension, and …

[HTML][HTML] Vitamin D deficiency and risk of metabolic syndrome in aging men

P D'Amelio - The world journal of men's health, 2021 - ncbi.nlm.nih.gov
The elderly population is rapidly increasing; hence, the disability due to age-related
diseases has become an important socioeconomic burden. Amongst age-related diseases …

[HTML][HTML] Peripheral circulating exosomal miRNAs potentially contribute to the regulation of molecular signaling networks in aging

H Zhang, K Jin - International Journal of Molecular Sciences, 2020 - mdpi.com
People are living longer than ever. Consequently, they have a greater chance for
developing a functional impairment or aging-related disease, such as a neurodegenerative …

The effect of raloxifene treatment on lipid profile in elderly individuals: a systematic review and meta-analysis of randomized clinical trials

H Shi, HO Santos, IGO de Souza, GJ Hoilat… - Clinical …, 2021 - Elsevier
Purpose To perform a systematic review and meta-analysis of randomized clinical trials
(RCTs) to elucidate the effects of raloxifene on the lipid profile in elderly individuals …

Genome‐wide profiles of DNA damage represent highly accurate predictors of mammalian age

H Cao, B Deng, T Song, J Lian, L Xia, X Chu… - Aging …, 2024 - Wiley Online Library
The identification of novel age‐related biomarkers represents an area of intense research
interest. Despite multiple studies associating DNA damage with aging, there is a glaring …

A cost‐effective blood DNA methylation‐based age estimation method in domestic cats, Tsushima leopard cats (Prionailurus bengalensis euptilurus) and Panthera …

H Qi, QL Lim, K Kinoshita, N Nakajima… - Molecular Ecology …, 2024 - Wiley Online Library
Individual age can be used to design more efficient and suitable management plans in both
in situ and ex situ conservation programmes for targeted wildlife species. DNA methylation is …