Palliative surgery for congenital heart disease has allowed patients with previously lethal
heart malformations to survive and, in most cases, to thrive. However, these procedures …

The neonatal capacity for cardiac regeneration in mice is well studied and has been used to
develop many potential strategies for adult cardiac regenerative repair following injury …

Heart failure is a major source of morbidity and mortality. Replacing lost myocardium with
new tissue is a major goal of regenerative medicine. Unlike adult mammals, zebrafish and …

Adult mammals undergo minimal regeneration following cardiac injury, which severely
compromises cardiac function and contributes to the ongoing burden of heart failure. In …

The adult human heart is an ideal target for regenerative intervention since it does not
functionally restore itself after injury yet has a modest regenerative capacity that could be …

Despite substantial advances, bona fide regeneration of the damaged human heart is still an
unmet ambition. By extracting our current knowledge from developmental biology, animal …

The adult mammalian heart is incapable of clinically relevant regeneration. The regenerative
deficit in adult mammalian heart contrasts with the fetal and neonatal heart, which …

Abstract Purpose of Review This review provides an overview of the molecular mechanisms
underpinning the cardiac regenerative capacity during the neonatal period and the potential …

Heart regeneration, a relatively new field of biology, is one of the most active and
controversial areas of biomedical research. The potential impact of successful human heart …

The death of cardiac myocytes diminishes the heart's pump function and is a major cause of
heart failure, one of the dominant causes of death worldwide. Other than transplantation …