Immune-associated gene signatures and subtypes to predict the progression of atherosclerotic plaques based on machine learning

Y Yang, X Yi, Y Cai, Y Zhang, Z Xu - Frontiers in pharmacology, 2022 - frontiersin.org
Objective: Experimental and clinical evidence suggests that atherosclerosis is a chronic
inflammatory disease. Our study was conducted for uncovering the roles of immune …

Identification of potential therapeutic targets for atherosclerosis by analysing the gene signature related to different immune cells and immune regulators in …

Y Shen, L Xu, X Tang, C Lin, D Yan, S Xue… - BMC Medical …, 2021 - Springer
Background Atherosclerosis is a chronic inflammatory disease that affects multiple arteries.
Numerous studies have shown the inherent immune diversity in atheromatous plaques and …

Identification and Validation of Candidate Gene Module Along With Immune Cells Infiltration Patterns in Atherosclerosis Progression to Plaque Rupture via …

J Xu, C Chen, Y Yang - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Objective To explore the differentially expressed genes (DEGs) along with infiltrating
immune cells landscape and their potential mechanisms in the progression of …

Six‐gene signature associated with immune cells in the progression of atherosclerosis discovered by comprehensive bioinformatics analyses

B Zhao, D Wang, Y Liu, X Zhang, Z Wan… - Cardiovascular …, 2020 - Wiley Online Library
Background. As a multifaceted disease, atherosclerosis is often characterized by the
formation and accumulation of plaque anchored to the inner wall of the arteries and causes …

Potential genes and pathways along with immune cells infiltration in the progression of atherosclerosis identified via microarray gene expression dataset re-analysis

J Xu, Y Yang - Vascular, 2020 - journals.sagepub.com
Objective Atherosclerosis is a chronic inflammatory process characterized by the
accumulation and formation of lipid-rich plaques within the layers of the arterial wall …

The integrated analysis identifies three critical genes as novel diagnostic biomarkers involved in immune infiltration in atherosclerosis

Z Ye, X Wang, Y Lv, X Wang, Y Cui - Frontiers in Immunology, 2022 - frontiersin.org
Atherosclerosis (AS), a chronic inflammatory disease of the blood vessels, is the primary
cause of cardiovascular disease, the leading cause of death worldwide. This study aimed to …

Bioinformatics analysis reveals the landscape of immune cell infiltration and immune-related pathways participating in the progression of carotid atherosclerotic …

L Tan, Q Xu, R Shi, G Zhang - Artificial Cells, Nanomedicine, and …, 2021 - Taylor & Francis
Atherosclerosis is a systemic disease associated with inflammatory cell infiltration and
activation of immune-related pathways. In our study, we aimed to uncover immune-related …

Analysis of immune and inflammation characteristics of atherosclerosis from different sample sources

H Nie, C Yan, W Zhou, T Li - Oxidative medicine and cellular …, 2022 - Wiley Online Library
Background. Atherosclerosis is the predominant cause of cardiovascular diseases. Existing
studies suggest that the development of atherosclerosis is closely related to inflammation …

Identifying potential signatures for atherosclerosis in the context of predictive, preventive, and personalized medicine using integrative bioinformatics approaches and …

J Xu, H Zhou, Y Cheng, G Xiang - EPMA Journal, 2022 - Springer
Background Atherosclerosis is a major contributor to morbidity and mortality worldwide.
Although several molecular markers associated with atherosclerosis have been developed …

Identification of immune cell infiltration and diagnostic biomarkers in unstable atherosclerotic plaques by integrated bioinformatics analysis and machine learning

J Wang, Z Kang, Y Liu, Z Li, Y Liu, J Liu - Frontiers in immunology, 2022 - frontiersin.org
Objective The decreased stability of atherosclerotic plaques increases the risk of ischemic
stroke. However, the specific characteristics of dysregulated immune cells and effective …