Background Although studies suggest a deficiency in stem cell numbers in chronic airway
diseases such as chronic obstructive pulmonary disease (COPD), the role of bronchial …

The alteration of progenitor/stem cells present in the airway epithelium has been observed
in patients with COPD. Smoking exposure induces remodeling patterns in bronchial …

Rationale: Up to 40% of smokers develop chronic obstructive pulmonary disease (COPD)
over a period that spans decades. Despite the importance of COPD, much remains to be …

Objectives: This study aimed to isolate and characterize stem/progenitor cells, starting from
normal airway epithelia, obtained from human adults. Materials and methods: Cultures of …

Background In the human lung, epithelial progenitor cells in the airways give rise to the
differentiated pseudostratified airway epithelium. In mice, emerging evidence confers a …

Chronic obstructive pulmonary disease (COPD) is a worldwide epidemic affecting over 200
million people and accounting for more than three million deaths annually. The disease is …

Lung-related diseases are the third-leading cause of human death throughout the world.
Lethal lung diseases such as chronic obstructive pulmonary disease (COPD), pulmonary …

Cigarette smoking, and the eventual development of chronic obstructive pulmonary disease
(COPD) in susceptible individuals, is characterized by disordered differentiation of the small …

Purpose Chronic obstructive pulmonary disease (COPD) patients experience hypoxemia
and lung tissue hypoxia, causing vasoconstriction, and at its most severe Cor pulmonale …

Objectives Chronic obstructive pulmonary disease (COPD) is characterized by irreversible
lung tissue damage including chronic bronchitis and emphysema, which could further …