Parkinson's disease (PD) is a common neurodegenerative disorder and is characterized by
the progressive loss of dopaminergic neurons in the substantia nigra. Although many …

Background Human α-synuclein is a small-sized, natively unfolded protein that in fibrillar
form is the primary component of Lewy bodies, the pathological hallmark of Parkinson's …

Convincing evidence supports the premise that reducing α-synuclein levels may be an
effective therapy for Parkinson's disease (PD); however, there has been lack of a clinically …

ABSTRACT α‐Synuclein (α‐syn) is a 140‐amino acid presinaptic protein whose mutations
A30P and A53T have been linked to familiar Parkinson's disease (PD). Many data suggest …

Alpha-synuclein (ASN) is a presynaptic protein that can easily change its conformation
under different types of stress. It's assumed that ASN plays an important role in the …

Both genetic and environmental factors are involved in the pathogenesis of Parkinsonos
disease (PD). Epidemiological studies showed that environmental factors shared with the …

Background The coexistence of α-synuclein and tau aggregates in several
neurodegenerative disorders, including Parkinson's disease and Alzheimer's disease …

Alpha-synuclein is a presynaptic protein which is implicated in some neurodegenerative
disorders including Parkinson's disease, dementia with Lewy bodies, multiple systems …

Multiple convergent lines of evidence implicate both α-synuclein (encoded by SCNA) and
mitochondrial dysfunction in the pathogenesis of sporadic Parkinson's disease (PD) …

Alpha synuclein protein may play an important role in familial and sporadic Parkinson's
disease pathology. We have induced G209A mutant or wild-type α-synuclein expression in …