Role of gasdermin family proteins in cancers
X Yang, Z Tang - International Journal of Oncology, 2023 - spandidos-publications.com
The gasdermin (GSDM) family comprises six proteins, including GSDMA‑GSDME and
Pejvakin. Most of these proteins have a crucial role in inducing pyroptosis; in particular …
Pejvakin. Most of these proteins have a crucial role in inducing pyroptosis; in particular …
Biological functions of gasdermins in cancer: from molecular mechanisms to therapeutic potential
M Wang, X Chen, Y Zhang - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Pyroptosis is a type of lytic programmed cell death triggered by various inflammasomes that
sense danger signals. Pyroptosis has recently attracted great attention owing to its …
sense danger signals. Pyroptosis has recently attracted great attention owing to its …
Role of pyroptosis in cancer and its therapeutic regulation
Pyroptosis is mainly considered a gasdermin-regulated cell death mechanism characterized
by cellular lysis and the release of several pro-inflammatory factors. Nowadays, pyroptosis …
by cellular lysis and the release of several pro-inflammatory factors. Nowadays, pyroptosis …
The pyroptotic and nonpyroptotic roles of gasdermins in modulating cancer progression and their perspectives on cancer therapeutics
SK Hsu, YE Chen, ED Shu, CC Ko, WT Chang… - Archivum Immunologiae …, 2023 - Springer
Gasdermins (GSDMs) are a protein family encoded by six paralogous genes in humans,
including GSDMA, GSDMB, GSDMC, GSDMD, GSDME (also known as DFNA5), and …
including GSDMA, GSDMB, GSDMC, GSDMD, GSDME (also known as DFNA5), and …
Pyroptosis and pyroptosis-inducing cancer drugs
Pyroptosis, an inflammatory form of lytic cell death, is a type of cell death mediated by the
gasdermin (GSDM) protein family. Upon recognizing exogenous or endogenous signals …
gasdermin (GSDM) protein family. Upon recognizing exogenous or endogenous signals …
Pyroptosis in cancer: friend or foe?
X Lu, T Guo, X Zhang - Cancers, 2021 - mdpi.com
Simple Summary Pyroptosis is a new form of programmed cell death that differs from
apoptosis in terms of its release of inflammatory factors and its characteristic bubble-like …
apoptosis in terms of its release of inflammatory factors and its characteristic bubble-like …
Pyroptosis, inflammasome, and gasdermins in tumor immunity
X Ouyang, J Zhou, L Lin, Z Zhang, S Luo… - Innate …, 2023 - journals.sagepub.com
The gasdermins (GSDM), a family of pore-forming proteins, consist of gasdermin A
(GSDMA), gasdermin B (GSDMB), gasdermin C (GSDMC), gasdermin D (GSDMD) …
(GSDMA), gasdermin B (GSDMB), gasdermin C (GSDMC), gasdermin D (GSDMD) …
Induction of pyroptosis and its implications in cancer management
YY Wang, XL Liu, R Zhao - Frontiers in oncology, 2019 - frontiersin.org
Pyroptosis is a gasdermins mediated programmed cell death, which has been widely
studied in inflammatory disease models. Recently, there are growing evidences that …
studied in inflammatory disease models. Recently, there are growing evidences that …
Role of GSDMB in pyroptosis and cancer
L Li, Y Li, Y Bai - Cancer Management and Research, 2020 - Taylor & Francis
Gasdermin B (GSDMB) belongs to the gasdermin (GSDM) family which may adopt different
mechanisms of intramolecular domain interactions to modulate their lipid-binding and pore …
mechanisms of intramolecular domain interactions to modulate their lipid-binding and pore …
[HTML][HTML] The multifaceted roles of gasdermins in cancer biology and oncologic therapies
D Sarrió, J Martínez-Val, Á Molina-Crespo… - … Et Biophysica Acta (BBA …, 2021 - Elsevier
The involvement of the Gasdermin (GSDM) protein family in cancer and other pathologies is
one of the hottest topics in biomedical research. There are six GSDMs in humans (GSDMA …
one of the hottest topics in biomedical research. There are six GSDMs in humans (GSDMA …