Background There is evidence that complex diseases and mortality are associated with DNA
methylation (DNAm) and age acceleration. Numerous epigenetic clocks, including Horvath …

Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …

As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …

In this review, we summarize current knowledge regarding the epigenetics of age-related
diseases, focusing on those studies that have described DNA methylation landscape in …

To date, a number of epigenetic clocks have been developed using DNA methylation data,
aimed at approximating biological aging in multiple tissues/cells. However, despite the …

Aging is the most important risk factor for major human lifestyle diseases, including cancer,
neurological and cardiometabolic disorders. Due to the complex interplay between genetics …

Epigenetic clocks are DNA methylation-based estimators of chronological age or mortality
risk that have been integrated into a wide array of epidemiologic studies. In this chapter, we …

Simone Ecker and Stephan Beck www. aging-us. com AGING 2019, Vol. 11, No. 2 www.
aging-us. com 833 AGING advantage over the multi-tissue clock which does not work well in …

It has been noted for quite some time that DNA methylation levels decline with age. The
significance of this change remained unknown until it became possible to measure …

Background Increasing life expectancy but also healthspan seems inaccessible as of yet but
it may become a reality in the foreseeable future. To extend lifespan, it is essential to unveil …