Objectives Age is the strongest risk factor of giant cell arteritis (GCA), implying a possible
pathogenetic role of cellular senescence. To address this question, we applied an …

Objective Giant cell arteritis (GCA) affects almost exclusively individuals above 50 years old,
suggesting a role of aging‐related changes such as cellular senescence in its pathobiology …

Susceptibility for giant cell arteritis increases with chronological age, in parallel with age-
related restructuring of the immune system and age-induced remodeling of the vascular …

Objective Giant cell arteritis (GCA) is the most frequently occurring vasculitis in elderly
individuals, and its pathogenesis is not fully understood. The objective of this study was to …

Background Search for therapeutic targets in giant-cell arteritis (GCA) is hampered by the
scarcity of functional systems. We developed a new model consisting of temporal artery …

Background Giant cell arteritis (GCA) is a primary large-vessel vasculitis (LVV) of unknown
origin. Its management is a challenge due to the late onset of disease symptoms and …

Objectives The pathogenesis of giant cell arteritis (GCA) remains unclear. TH1 and TH17
pathways are implicated, but the proximal initiators and effector cytokines are unknown. Our …

Aging is characterized by the functional decline of the immune system and constitutes the
primary risk factor for infectious diseases, cardiovascular disorders, cancer, and …

The giant cell arteritis (GCA) pathophysiology is complex and multifactorial, involving a
predisposing genetic background, the role of immune aging and the activation of vascular …

Objective. GCA is a large-and medium-vessel arteritis characterized by a range of
histological patterns of vascular wall injury. The aim of this study was to immunologically …