Background Immune responses to COVID-19 mRNA vaccines have not been well
characterized in frail older adults. We postulated that frailty is associated with impaired …

Background COVID-19 has disproportionately affected older adults. Frailty has been
associated with impaired vaccine response in other vaccine types, but the impact of frailty on …

Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
effective in preventing COVID-19 hospitalization and fatal outcome. However, several …

Background Male sex and old age are risk factors for severe COVID-19, but the intersection
of sex and aging on antibody responses to SARS-CoV-2 vaccines has not been …

Knowledge about the impact of prior severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection of the elderly on mRNA vaccination response is needed to …

Background Older age is associated with poorer outcomes to COVID-19 infection. The
Norwegian Institute of Public Health established a longitudinal cohort of adults aged 65–80 …

Background The magnitude and durability of immune responses to coronavirus disease
2019 (COVID-19) mRNA vaccines remain incompletely characterized in the elderly …

Whether age-associated defects in T cells impact the immunogenicity and reactogenicity of
mRNA vaccines remains unclear. Using a vaccinated cohort (n= 216), we demonstrated that …

Background The use of COVID-19 vaccines has been prioritised to protect the most
vulnerable—notably, older people. Because of fluctuations in vaccine availability, strategies …

Abstract Knowledge about the impact of prior SARS-CoV-2 infection of the elderly on mRNA
vaccination response is needed to appropriately address the need for booster vaccination in …