Role of PI3K/Akt-mediated Nrf2/HO-1 signaling pathway in resveratrol alleviation of zearalenone-induced oxidative stress and apoptosis in TM4 cells

W Xu, H Zheng, Y Fu, Y Gu, H Zou, Y Yuan, J Gu, Z Liu… - Toxins, 2022 - mdpi.com
Zearalenone (ZEA) is a common mycotoxin that induces oxidative stress (OS) and affects the
male reproductive system in animals. Resveratrol (RSV) has good antioxidant activity and …

The protective effect of resveratrol against cytotoxicity induced by mycotoxin, zearalenone

Y Sang, W Li, G Zhang - Food & function, 2016 - pubs.rsc.org
Zearalenone (ZEA), a non-steroidal estrogenic mycotoxin, is widely present in cereals and
agricultural products. The literature reports suggest that oxidative damage seems to be a key …

Procyanidins inhibit zearalenone-induced apoptosis and oxidative stress of porcine testis cells through activation of Nrf2 signaling pathway

R Yan, H Wang, J Zhu, T Wang, E Nepovimova… - Food and Chemical …, 2022 - Elsevier
The mycotoxin zearalenone (ZEA) in food and feed seriously harms human and animal
health. How to reduce its toxicity is an important direction of current research on food safety …

Curcumin inhibits zearalenone-induced apoptosis and oxidative stress in Leydig cells via modulation of the PTEN/Nrf2/Bip signaling pathway

S Chen, S Yang, M Wang, J Chen, S Huang… - Food and chemical …, 2020 - Elsevier
The toxic effect of zearalenone (ZEA) is not fully understood and there is an urgent need for
the development of effective agents to protect against the toxic effects of ZEA. In this study …

[HTML][HTML] Lycopene attenuates zearalenone-induced oxidative damage of piglet sertoli cells through the nuclear factor erythroid-2 related factor 2 signaling pathway

L Cao, J Zhao, L Ma, J Chen, J Xu, SU Rahman… - Ecotoxicology and …, 2021 - Elsevier
Zearalenone (ZEA) has an estrogenic effect and often causes reproductive damage. Pigs
are particularly sensitive to it. Lycopene (LYC) is a type of fat-soluble natural carotenoid that …

ROS-mediated cell cycle arrest and apoptosis induced by zearalenone in mouse sertoli cells via ER stress and the ATP/AMPK pathway

WL Zheng, BJ Wang, L Wang, YP Shan, H Zou… - Toxins, 2018 - mdpi.com
Zearalenone (ZEA) can perturb the differentiation of cells, reduce the generation of
reproductive cells and induce a death of germ cells, but the molecular mechanism remains …

Protective effect of proanthocyanidin on mice Sertoli cell apoptosis induced by zearalenone via the Nrf2/ARE signalling pathway

M Long, SH Yang, W Shi, P Li, Y Guo, J Guo… - … Science and Pollution …, 2017 - Springer
This study evaluated the protective effect of proanthocyanidin (PC) on the cytotoxicity of the
Sertoli cell TM4 of mice, as induced by zearalenone (ZEA). Flow cytometry was used to …

Proanthocyanidin protects against acute zearalenone-induced testicular oxidative damage in male mice

M Long, S Yang, Y Zhang, P Li, J Han, S Dong… - … Science and Pollution …, 2017 - Springer
Zearalenone (ZEN) exerts a major effect on human and animal health and has led to serious
worldwide economic problems. In this study, we investigated whether proanthocyanidin (PC) …

Mycotoxin zearalenone induces AIF-and ROS-mediated cell death through p53-and MAPK-dependent signaling pathways in RAW264. 7 macrophages

JY Yu, ZH Zheng, YO Son, X Shi, YO Jang, JC Lee - Toxicology in Vitro, 2011 - Elsevier
Zearalenone (ZEN) is commonly found in many food commodities and is known to cause
reproductive disorders and genotoxic effects. However, the mode of ZEN-induced cell death …

Resveratrol attenuates hydrogen peroxide-induced injury of rat ovarian granulosa-lutein cells by resisting oxidative stress via the SIRT1/Nrf2/ARE signaling pathway

M Cai, J Wang, H Sun, Q Guo, C Zhang… - Current …, 2023 - ingentaconnect.com
Introduction: This paper aims to reveal the molecular mechanism of resveratrol against
oxidative stress and cell injury. The ovarian granulosa-lutein cell injury and apoptosis …