Abstract 'Immunosenescence'is an imprecise term used to describe deleterious age‐
associated changes to immune parameters observed in all mammals studied so far …

Abstract “Immunosenescence” is a loosely descriptive designation for age-associated
alterations to most measures of immunity, which can be seen in all mammals examined in …

The mammalian immune system defends the organism against pathogens, and possibly
cancer, but is known to become dysregulated with increasing age. This results in greater …

Since Looney at al. published their seminal paper a decade ago [1] it has become clear that
many of the differences in T cell immunological parameters observed between young and …

In the year 2000, cytomegalovirus was identified as a risk factor for mortality in a seminal
study of octogenarian residents in Sweden. This finding triggered a wave of additional …

The human immune system evolved to defend the organism against pathogens, but is
clearly less well able to do so in the elderly, resulting in greater morbidity and mortality due …

Ageing is associated with a decline in immune competence termed immunosenescence. In
the elderly, this process results in an accumulation of differentiated 'effector'phenotype …

Cytomegalovirus (CMV) is a common herpesvirus infection and stimulates the expansion of
very large numbers of CMV‐specific T cells that reduce the CD 4/CD 8 ratio and suppress …

Dysregulated immunity,'immunosenescence', in the elderly is thought to contribute to their
increased susceptibility to infectious disease and to impact on mortality. Accepted hallmarks …

Introduction Immunosenescence is the age-related deterioration of immunocompetence
which is reflected in a poorer response to new antigens. This process is characterized by …