The impact of life stress on hallmarks of aging and accelerated senescence: Connections in sickness and in health

CE Lyons, M Razzoli, A Bartolomucci - Neuroscience & Biobehavioral …, 2023 - Elsevier
Chronic stress is a risk factor for numerous aging-related diseases and has been shown to
shorten lifespan in humans and other social mammals. Yet how life stress causes such a …

[HTML][HTML] Stress-induced biological aging: A review and guide for research priorities

LR Polsky, KE Rentscher, JE Carroll - Brain, behavior, and immunity, 2022 - Elsevier
Exposure to chronic adverse conditions, and the resultant activation of the neurobiological
response cascade, has been associated with an increased risk of early onset of age-related …

Stress and Alzheimer's disease: A senescence link?

CE Lyons, A Bartolomucci - Neuroscience & biobehavioral reviews, 2020 - Elsevier
Chronic stress has been shown to promote numerous aging-related diseases, and to
accelerate the aging process itself. Of particular interest is the impact of stress on …

[HTML][HTML] The geroscience agenda: Toxic stress, hormetic stress, and the rate of aging

ES Epel - Ageing Research Reviews, 2020 - Elsevier
Geroscience offers a counterpoint to the challenged pursuit of curing diseases of aging, by
focusing on slowing the biological aging process for extended healthspan earlier in life …

Social stress shortens lifespan in mice

M Razzoli, K Nyuyki‐Dufe, A Gurney, C Erickson… - Aging cell, 2018 - Wiley Online Library
Stress and low socioeconomic status in humans confer increased vulnerability to morbidity
and mortality. However, this association is not mechanistically understood nor has its …

Stress biology and aging mechanisms: toward understanding the deep connection between adaptation to stress and longevity

ES Epel, GJ Lithgow - Journals of Gerontology Series A …, 2014 - academic.oup.com
The rate of biological aging is modulated in part by genes interacting with stressor
exposures. Basic research has shown that exposure to short-term stress can strengthen …

Epigenetics as a key link between psychosocial stress and aging: concepts, evidence, mechanisms

AS Zannas - Dialogues in clinical neuroscience, 2019 - Taylor & Francis
Psychosocial stress—especially when chronic, excessive, or occurring early in life—has
been associated with accelerated aging and increased disease risk. With rapid aging of the …

Aging, inflammation and the environment

A Bektas, SH Schurman, R Sen, L Ferrucci - Experimental gerontology, 2018 - Elsevier
The aging process is driven by interrelated mechanisms that lead to the emergence of
characteristic phenotypes that include changes in body composition, energy production and …

Stress and ageing interactions: a paradox in the context of shared etiological and physiopathological processes

MC Pardon - Brain research reviews, 2007 - Elsevier
Gerontology has made considerable progress in the understanding of the mechanisms
underlying the ageing process and age-related neurodegenerative disorders. However …

Measuring biological aging in humans: A quest

L Ferrucci, M Gonzalez‐Freire, E Fabbri… - Aging cell, 2020 - Wiley Online Library
The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …