Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
The genetic contribution to the variation in human lifespan is∼ 25%. Despite the large
number of identified disease-susceptibility loci, it is not known which loci influence …
number of identified disease-susceptibility loci, it is not known which loci influence …
Genome‐wide linkage analysis for human longevity: Genetics of Healthy Aging Study
Clear evidence exists for heritability of human longevity, and much interest is focused on
identifying genes associated with longer lives. To identify such longevity alleles, we …
identifying genes associated with longer lives. To identify such longevity alleles, we …
[HTML][HTML] A meta-analysis of genome-wide association studies identifies multiple longevity genes
Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …
Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
By studying the loci that contribute to human longevity, we aim to identify mechanisms that
contribute to healthy aging. To identify such loci, we performed a genome‐wide association …
contribute to healthy aging. To identify such loci, we performed a genome‐wide association …
[HTML][HTML] Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants
Variation in human lifespan is 20 to 30% heritable in twins but few genetic variants have
been identified. We undertook a Genome Wide Association Study (GWAS) using age at …
been identified. We undertook a Genome Wide Association Study (GWAS) using age at …
The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals
JM Murabito, R Yuan, KL Lunetta - Journals of Gerontology …, 2012 - academic.oup.com
Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …
the identification of the underlying genes remains a challenge. Longevity is a complex …
[HTML][HTML] Historical demography and longevity genetics: back to the future
Research into the genetic component of human longevity can provide important insights in
mechanisms that may protect against age-related diseases and multi-morbidity. Thus far …
mechanisms that may protect against age-related diseases and multi-morbidity. Thus far …
[HTML][HTML] Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
Background Family studies and heritability estimates provide evidence for a genetic
contribution to variation in the human life span. Methods We conducted a genome wide …
contribution to variation in the human life span. Methods We conducted a genome wide …
Integrated genetic analyses revealed novel human longevity loci and reduced risks of multiple diseases in a cohort study of 15,651 Chinese individuals
There is growing interest in studying the genetic contributions to longevity, but limited
relevant genes have been identified. In this study, we performed a genetic association study …
relevant genes have been identified. In this study, we performed a genetic association study …
A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals
A Nebel, R Kleindorp, A Caliebe, M Nothnagel… - Mechanisms of ageing …, 2011 - Elsevier
We conducted a case–control genome-wide association study (GWAS) of human longevity,
comparing 664,472 autosomal SNPs in 763 long-lived individuals (LLI; mean age: 99.7 …
comparing 664,472 autosomal SNPs in 763 long-lived individuals (LLI; mean age: 99.7 …