EZH2: a novel target for cancer treatment
R Duan, W Du, W Guo - Journal of hematology & oncology, 2020 - Springer
Enhancer of zeste homolog 2 (EZH2) is enzymatic catalytic subunit of polycomb repressive
complex 2 (PRC2) that can alter downstream target genes expression by trimethylation of …
complex 2 (PRC2) that can alter downstream target genes expression by trimethylation of …
Targeting EZH2 for cancer therapy: progress and perspective
C Han Li, Y Chen - Current Protein and Peptide Science, 2015 - ingentaconnect.com
Enhancer of Zeste Homolog 2 (EZH2) is the core component of the polycomb repressive
complex 2 (PRC2), possessing the enzymatic activity in generating di/tri-methylated lysine …
complex 2 (PRC2), possessing the enzymatic activity in generating di/tri-methylated lysine …
[HTML][HTML] EZH2 in normal hematopoiesis and hematological malignancies
Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb repressive
complex 2, inhibits gene expression through methylation on lysine 27 of histone H3. EZH2 …
complex 2, inhibits gene expression through methylation on lysine 27 of histone H3. EZH2 …
The roles of EZH2 in cancer and its inhibitors
Y Liu, Q Yang - Medical Oncology, 2023 - Springer
The enhancer of zeste homolog 2 (EZH2) is encoded by the Enhancer of zeste 2 polycomb
repressive complex 2 subunit gene. EZH2 is involved in the cell cycle, DNA damage repair …
repressive complex 2 subunit gene. EZH2 is involved in the cell cycle, DNA damage repair …
Post-translational modifications of EZH2 in cancer
Z Li, M Li, D Wang, P Hou, X Chen, S Chu, D Chai… - Cell & bioscience, 2020 - Springer
Enhancer of zeste homolog 2 (EZH2), as a main component of Polycomb Repressive
Complex 2, catalyzes histone H3K27me3 to silence its target gene expression. EZH2 …
Complex 2, catalyzes histone H3K27me3 to silence its target gene expression. EZH2 …
[HTML][HTML] Regulation and role of EZH2 in cancer
H Yamaguchi, MC Hung - Cancer research and treatment …, 2014 - synapse.koreamed.org
Abstract Polycomb repressive complex 2 (PRC2) is the epigenetic regulator that induces
histone H3 lysine 27 methylation (H3K27me3) and silences specific gene transcription …
histone H3 lysine 27 methylation (H3K27me3) and silences specific gene transcription …
Targeting EZH2 as cancer therapy
S Hanaki, M Shimada - The journal of biochemistry, 2021 - academic.oup.com
Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive
complex 2 (PRC2) that mediate repression of target genes by trimethylation of Lys27 in …
complex 2 (PRC2) that mediate repression of target genes by trimethylation of Lys27 in …
Epigenetic regulation of cancer progression by EZH2: from biological insights to therapeutic potential
L Gan, Y Yang, Q Li, Y Feng, T Liu, W Guo - Biomarker research, 2018 - Springer
Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a catalytic
component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to …
component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to …
Targeting histone methyltransferase EZH2 as cancer treatment
Y Kondo - The journal of biochemistry, 2014 - academic.oup.com
It is widely accepted that epigenetic alterations are associated with different stages of tumour
formation and progression in many cancers. Therefore, epigenetic abnormalities in cancers …
formation and progression in many cancers. Therefore, epigenetic abnormalities in cancers …
EZH2-targeted therapies in cancer: hype or a reality
ML Eich, M Athar, JE Ferguson III, S Varambally - Cancer research, 2020 - AACR
Next-generation genomic sequencing has identified multiple novel molecular alterations in
cancer. Since the identification of DNA methylation and histone modification, it has become …
cancer. Since the identification of DNA methylation and histone modification, it has become …