The liver is the main gateway from the gut, and the unidirectional sinusoidal flow from portal
to central veins constitutes heterogenous zones, including the periportal vein (PV) and the …

The liver connects the intestinal portal vasculature with the general circulation, using a
diverse array of immune cells to protect from pathogens that translocate from the gut. In liver …

While the ontogeny and recruitment of the intestinal monocyte/macrophage lineage has
been studied extensively, their precise localization and function has been overlooked. Here …

The intestinal immune system is highly adapted to maintaining tolerance to the commensal
microbiota and self-antigens while defending against invading pathogens,. Recognizing …

The commensal flora can promote both immunity to pathogens and mucosal inflammation.
How commensal-driven inflammation is regulated in the context of infection remains poorly …

A prerequisite for establishment of mutualism between the host and the microbial community
that inhabits the large intestine is the stringent mucosal compartmentalization of …

Kupffer cells (KCs) are localized in liver sinusoids but extend pseudopods to parenchymal
cells to maintain their identity and serve as the body's central bacterial filter. Liver cirrhosis …

INTRODUCTION The liver's remarkable capacity to maintain proper tissue mass after injury
has been known since ancient times. However, there has been considerable debate about …

Liver dysfunction is an early event in sepsis-related multi-organ failure. We here report the
establishment and characterization of a microfluidically supported in vitro organoid model of …

Macrophages are found throughout the body, where they have crucial roles in tissue
development, homeostasis and remodeling, as well as being sentinels of the innate immune …