[PDF][PDF] Hallmarks of response, resistance, and toxicity to immune checkpoint blockade

G Morad, BA Helmink, P Sharma, JA Wargo - Cell, 2021 - cell.com
Unprecedented advances have been made in cancer treatment with the use of immune
checkpoint blockade (ICB). However, responses are limited to a subset of patients, and …

[HTML][HTML] Mechanisms of tumor resistance to immune checkpoint blockade and combination strategies to overcome resistance

X Zhou, Y Ni, X Liang, Y Lin, B An, X He… - Frontiers in …, 2022 - frontiersin.org
Immune checkpoint blockade (ICB) has rapidly transformed the treatment paradigm for
various cancer types. Multiple single or combinations of ICB treatments have been approved …

[HTML][HTML] Immune checkpoint blockade in cancer treatment: a double-edged sword cross-targeting the host as an “innocent bystander”

L Gelao, C Criscitiello, A Esposito, A Goldhirsch… - Toxins, 2014 - mdpi.com
Targeted immune checkpoint blockade augments anti-tumor immunity and induces durable
responses in patients with melanoma and other solid tumors. It also induces specific …

Mechanisms of resistance to immune checkpoint blockade: why does checkpoint inhibitor immunotherapy not work for all patients?

CM Fares, EM Van Allen, CG Drake… - American Society of …, 2019 - ascopubs.org
The emergence of immune checkpoint blockade therapies over the last decade has
transformed cancer treatment in a wide range of tumor types. Unprecedented and durable …

[HTML][HTML] Hallmarks of response to immune checkpoint blockade

AP Cogdill, MC Andrews, JA Wargo - British journal of cancer, 2017 - nature.com
Unprecedented advances have been made in the treatment of cancer through the use of
immune checkpoint blockade, with approval of several checkpoint blockade regimens …

Intrinsic resistance of solid tumors to immune checkpoint blockade therapy

X Zhao, S Subramanian - Cancer research, 2017 - AACR
Immune checkpoint blockade therapy (ICBT), which blocks negative immune-activating
signals and maintains the antitumor response, has elicited a remarkable clinical response in …

Immune checkpoint therapy—current perspectives and future directions

P Sharma, S Goswami, D Raychaudhuri, BA Siddiqui… - Cell, 2023 - cell.com
Immune checkpoint therapy (ICT) has dramatically altered clinical outcomes for cancer
patients and conferred durable clinical benefits, including cure in a subset of patients …

The next decade of immune checkpoint therapy

P Sharma, BA Siddiqui, S Anandhan, SS Yadav… - Cancer discovery, 2021 - AACR
Immune checkpoint therapy (ICT) can provide durable clinical responses and improve
overall survival. However, only subsets of patients with specific tumor types respond to ICT …

Immune checkpoint inhibitors for the treatment of cancer: clinical impact and mechanisms of response and resistance

S Bagchi, R Yuan, EG Engleman - Annual Review of Pathology …, 2021 - annualreviews.org
Immune checkpoint inhibitors (ICIs) have made an indelible mark in the field of cancer
immunotherapy. Starting with the approval of anti-cytotoxic T lymphocyte-associated protein …

Mutational landscape and sensitivity to immune checkpoint blockers

RM Chabanon, M Pedrero, C Lefebvre… - Clinical Cancer …, 2016 - AACR
Immunotherapy is currently transforming cancer treatment. Notably, immune checkpoint
blockers (ICB) have shown unprecedented therapeutic successes in numerous tumor types …