Flavonoid delivery by solid dispersion: a systematic review

M Colombo, LR Michels, HF Teixeira… - Phytochemistry Reviews, 2022 - Springer
The poor water solubility of flavonoids represents the greatest challenge to increasing the
oral bioavailability of these compounds. Nevertheless, several potential positive effects of …

Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview

J Zhao, J Yang, Y Xie - International journal of pharmaceutics, 2019 - Elsevier
Although flavonoid compounds have various pharmacological applications, they generally
exhibit low oral bioavailability due to their poor aqueous solubility. To address this problem …

Exploring the potential of solid dispersion for improving solubility, dissolution & bioavailability of herbal extracts, enriched fractions, and bioactives

D Mohapatra, AK Agrawal, AN Sahu - Journal of …, 2021 - Taylor & Francis
Most drugs' poor aqueous solubility has emerged as a significant challenge in achieving
proper therapeutic response following oral administration. Herbal drugs are being used from …

[HTML][HTML] Enhancing therapeutic potential of poor aqueous soluble herbal drugs through solid dispersion-An overview

SUD Wani, V Kakkar, SP Gautam… - Phytomedicine Plus, 2021 - Elsevier
Background Poorly water-soluble medicaments continue to be a challenging, however,
significant class of herbal drugs for the management of an extensive range of ailments. Solid …

Trends in oral flavonoid drug delivery systems based on current pharmaceutical strategies. A systematic patent review (2011-2023)

IAR Martínez, PS Londoño-Ruíz, MR Serafini… - Journal of Herbal …, 2023 - Elsevier
Secondary metabolites of plants have been proposed as sources of multiple benefits in
different fields. Flavonoids are a subtype of them with medicinal effects as anti-viral/bacterial …

[PDF][PDF] Encapsulation systems for delivery of flavonoids: A

M Yousefi, M Shadnoush… - … Res. Appl. Chem, 2021 - biointerfaceresearch.com
Encapsulation of bioactive compounds s been considered a promising tool for preserving
these compounds. Several studies on dietary sources and health benefits of flavonoids, their …

Recent advances in topical delivery of flavonoids: A review

RL Nagula, S Wairkar - Journal of controlled release, 2019 - Elsevier
Flavonoids are one of the vital classes of bioactive chemicals, abundantly found in plants.
These are natural polyphenolic compounds derived from plant metabolites. Their lipophilic …

Oral delivery of hydrophobic flavonoids and their incorporation into functional foods: Opportunities and challenges

R Premathilaka, A Rashidinejad, M Golding, J Singh - Food Hydrocolloids, 2022 - Elsevier
Flavonoids have long been known for their healing powers in human ailments, with recent
trends seeing these natural bioactive components increasingly extended into nutraceuticals …

[HTML][HTML] Flavonoids loaded in nanocarriers: an opportunity to increase oral bioavailability and bioefficacy

AR Bilia, B Isacchi, C Righeschi, C Guccione… - Food and Nutrition …, 2014 - scirp.org
Flavonoids are among the biggest group of polyphenols, widely distributed in plant-based
foods. A plethora of evidence supports the health benefits and value of flavonoids can play …

The potential application of novel drug delivery systems for phytopharmaceuticals and natural extracts–current status and future perspectives

MF Mahomoodally, N Sadeer, M Edoo… - Mini Reviews in …, 2021 - ingentaconnect.com
Phytocompounds isolated from plants are well appraised for their broad pharmacological
propensities in several pathologies. One key benefit of phytoconstituents is their relatively …