Systemic inflammation and the increased risk of inflamm-aging and age-associated diseases in people living with HIV on long term suppressive antiretroviral therapy

H Babu, AT Ambikan, EE Gabriel… - Frontiers in …, 2019 - frontiersin.org
The ART program in low-and middle-income countries (LMIC) like India, follows a public
health approach with a standardized regimen for all people living with HIV (PLHIV). Based …

Inflammatory co-morbidities in HIV+ individuals: learning lessons from healthy ageing

AC Hearps, GE Martin, R Rajasuriar… - Current HIV/AIDS …, 2014 - Springer
Increased life expectancy due to improved efficacy of cART has uncovered an increased risk
of age-related morbidities in HIV+ individuals and catalyzed significant research into …

Managing HIV‐associated inflammation and ageing in the era of modern ART

M Bloch, M John, D Smith, TA Rasmussen… - HIV …, 2020 - Wiley Online Library
Objectives This paper aims to address the concerns around ongoing immune activation,
inflammation, and resistance in those ageing with HIV that represent current challenges for …

Basic science and pathogenesis of ageing with HIV: potential mechanisms and biomarkers

C Lagathu, A Cossarizza, V Béréziat, M Nasi, J Capeau… - Aids, 2017 - journals.lww.com
The increased prevalence of age-related comorbidities and mortality is worrisome in ageing
HIV-infected patients. Here, we aim to analyse the different ageing mechanisms with regard …

Immune dysfunction, inflammation, and accelerated aging in patients on antiretroviral therapy.

SG Deeks - Topics in HIV medicine: a publication of the …, 2009 - europepmc.org
Patients receiving long-term antiretroviral therapy are at increased risk of age-associated
non-AIDS-related morbidity and mortality compared with HIV-seronegative persons. Despite …

Ageing and inflammation in patients with HIV infection

M Nasi, S De Biasi, L Gibellini… - Clinical & …, 2017 - academic.oup.com
Nowadays, HIV+ patients have an expected lifespan that is only slightly shorter than healthy
individuals. For this reason, along with the fact that infection can be acquired at a relatively …

Aging with HIV infection: a journey to the center of inflammAIDS, immunosenescence and neuroHIV

M Nasi, M Pinti, S De Biasi, L Gibellini, D Ferraro… - Immunology letters, 2014 - Elsevier
In the last years, a significant improvement in life expectancy of HIV+ patients has been
observed in Western countries. The parallel increase in the mean age of these patients …

A review of premature frailty in HIV-infected persons; another manifestation of HIV-related accelerated aging

NF Onen, E Turner Overton - Current aging science, 2011 - ingentaconnect.com
Purpose: HIV-related immunological and multisystem accelerated aging contributes to the
premature occurrence of agerelated comorbidities. Such non-AIDS-defining comorbidities …

Association of functional impairment with inflammation and immune activation in HIV type 1–infected adults receiving effective antiretroviral therapy

KM Erlandson, AA Allshouse… - The Journal of …, 2013 - academic.oup.com
Background. The relationships of inflammation, immune activation, and immunosenescence
markers with functional impairment in aging human immunodeficiency virus type 1 (HIV-1) …

Immune activation in HIV-infected aging women on antiretrovirals—implications for age-associated comorbidities: a cross-sectional pilot study

ML Alcaide, A Parmigiani, S Pallikkuth, M Roach… - PloS one, 2013 - journals.plos.org
Background Persistent immune activation and microbial translocation associated with HIV
infection likely place HIV-infected aging women at high risk of developing chronic age …