Introduction Sepsis is the leading cause of death in intensive care units and is characterized
by multiple organ failure, including dysfunction of the immune system. In the present study …

Purpose Sepsis, with life-threatening organ failure, is caused by the uncontrolled host
response to infection. Immune response plays an important role in the pathophysiology of …

Abstract Background Immune-related genes (IRGs) remain poorly understood in their
function in the onset and progression of sepsis. Methods GSE65682 was obtained from the …

A growing body of evidence indicates that the immune system plays a central role in sepsis.
By analyzing immune genes, we sought to establish a robust gene signature and develop a …

Due to the low specificity and sensitivity of biomarkers in sepsis diagnostics, the prognosis of
sepsis patient outcomes still relies on the assessment of clinical symptoms. Inflammatory …

Background Sepsis is a highly heterogeneous syndrome with stratified severity levels and
immune states. Even in patients with similar clinical appearances, the underlying signal …

Background: Sepsis is well-known to alter innate and adaptive immune responses for
sustained periods after initiation by an invading pathogen. Identification of immune cell …

Objective Sepsis is linked to high morbidity and mortality rates. Consequently, early
diagnosis is crucial for proper treatment, reducing hospitalization, and mortality rates …

Background. Novel biomarkers are needed to progress towards individualized patient care
in sepsis. The immune profiling panel (IPP) prototype has been designed as a fully …

A complicated clinical course for critically ill patients admitted to the intensive care unit (ICU)
usually includes multiorgan dysfunction and subsequent death. Owing to the heterogeneity …