Differential outcomes of infection by wild-type SARS-CoV-2 and the B. 1.617. 2 and B. 1.1. 529 variants of concern in K18-hACE2 transgenic mice

Y He, J Henley, P Sell, L Comai - Viruses, 2023 - mdpi.com
Background: SARS-CoV-2 is a respiratory virus with neurological complications including
the loss of smell and taste, headache, and confusion that can persist for months or longer …

Virulence profiles of wild-type, P. 1 and Delta SARS-CoV-2 variants in K18-hACE2 transgenic mice

Y da Silva Santos, THM Gamon, MSP de Azevedo… - Viruses, 2023 - mdpi.com
Since December 2019, the world has been experiencing the COVID-19 pandemic caused
by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and we now face …

Heterogeneous infectivity and pathogenesis of SARS-CoV-2 variants beta, delta and omicron in transgenic K18-hACE2 and wildtype mice

F Tarrés-Freixas, B Trinité, A Pons-Grífols… - Frontiers in …, 2022 - frontiersin.org
The emerging SARS-CoV-2 variants of concern (VOCs) may display enhanced
transmissibility, more severity and/or immune evasion; however, the pathogenesis of these …

[HTML][HTML] Comparison of the pathogenicity of SARS-CoV-2 Delta and Omicron variants by analyzing the expression patterns of immune response genes in K18-hACE2 …

KAPP Kuruppuarachchi, Y Jang… - Frontiers in Bioscience …, 2022 - imrpress.com
Background: The recently emerged variants of the severe acute respiratory coronavirus 2
(SARS-CoV-2) pose a threat to public health. Understanding the pathogenicity of these …

Differential pathogenesis of SARS-CoV-2 variants of concern in human ACE2-expressing mice

JP Natekar, H Pathak, S Stone, P Kumari, S Sharma… - Viruses, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the current
pandemic, resulting in millions of deaths worldwide. Increasingly contagious variants of …

Characterization of three variants of SARS-CoV-2 In vivo shows host-dependent pathogenicity in hamsters, while not in K18-hACE2 mice

G Toomer, W Burns, L Garcia, G Henry, A Biancofiori… - Viruses, 2022 - mdpi.com
Animal models are used in preclinical trials to test vaccines, antivirals, monoclonal
antibodies, and immunomodulatory drug therapies against SARS-CoV-2. However, these …

Hamsters expressing human angiotensin-converting enzyme 2 develop severe disease following exposure to SARS-CoV-2

JW Golden, R Li, CR Cline, X Zeng, EM Mucker… - MBio, 2022 - Am Soc Microbiol
The rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has created a global health emergency. While most human disease is mild to moderate …

Characterization of the SARS-CoV-2 BA. 5.5 and BQ. 1.1 Omicron variants in mice and hamsters

JB Case, SM Scheaffer, TL Darling, TL Bricker… - Journal of …, 2023 - Am Soc Microbiol
The continued evolution and emergence of novel severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) variants have resulted in challenges to vaccine and antibody …

SARS-CoV-2 B. 1.1. 7 (alpha) and B. 1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains

P Radvak, HJ Kwon, M Kosikova… - Nature …, 2021 - nature.com
SARS-CoV-2 variants of concern (VOC) B. 1.1. 7 (alpha) and B. 1.351 (beta) show increased
transmissibility and enhanced antibody neutralization resistance. Here we demonstrate in …

Mouse-Adapted SARS-CoV-2 MA10 Strain Displays Differential Pulmonary Tropism and Accelerated Viral Replication, Neurodissemination, and Pulmonary Host …

CJ Thieulent, W Dittmar, UBR Balasuriya… - Msphere, 2023 - Am Soc Microbiol
Several models were developed to study the pathogenicity of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) as well as the in vivo efficacy of vaccines and …