DNA methylation aging clocks have become an invaluable tool in biogerontology research
since their inception in 2013. Today, a variety of machine learning approaches have been …

Several age predictors based on DNA methylation, dubbed epigenetic clocks, have been
created in recent years, with the vast majority based on regularized linear regression. This …

Motivation Ageing is a biological and psychosocial process related to diseases and
mortality. It correlates with changes in DNA methylation (DNAm) in all human tissues …

Human DNA methylation data have been used to develop biomarkers of ageing, referred to
as 'epigenetic clocks', which have been widely used to identify differences between …

Epigenetic clock, a highly accurate age estimator based on DNA methylation (DNAm) level,
is the basis for predicting mortality/morbidity and elucidating the molecular mechanism of …

Background DNA methylation changes with age. Chronological age predictors built from
DNA methylation are termed 'epigenetic clocks'. The deviation of predicted age from the …

The biological markers of aging used to predict physical health status in older people are of
great interest. Telomere shortening, which occurs during the process of cell replication, was …

Background Age-associated DNA methylation changes provide a promising biomarker for
the aging process. While genome-wide DNA methylation profiles enable robust age …

All tissues of organisms will become old as time goes on. In recent years, epigenetic
investigations have found that there is a close correlation between DNA methylation and …

Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …