Aging leads to a progressive functional decline of the immune system, rendering the elderly
increasingly susceptible to disease and infection. The degree to which immune cell …

Immunosenescence is characterized by phenotypic and functional changes of effector
memory T cells. In spite of the well-described senescent defects of these experienced T …

The ageing of the global population brings about unprecedented challenges. Chronic age‐
related diseases in an increasing number of people represent an enormous burden for …

The strict limit in proliferative potential of normal human somatic cells–a process known as
replicative senescence–is highly relevant to the immune system, because clonal expansion …

The progression of physiological ageing is driven by intracellular aberrations including
telomere attrition, genomic instability, epigenetic alterations and loss of proteostasis. These …

The decline of the immune system appears to be an intractable consequence of aging,
leading to increased susceptibility to infections, reduced effectiveness of vaccination and …

Cellular senescence is accompanied by a senescence‐associated secretory phenotype
(SASP). We show here that primary human senescent CD 8+ T cells also display a SASP …

When encountering foreign antigens, naïve T cells become activated and differentiate into
effector and memory T cells. They represent therefore the primary source to mount an …

Cellular senescence, a state of irreversible cell cycle arrest, is a robust mechanism used to
mediate tumor suppression and control the tissue damage response following short-term …

Immune cells with a senescence-associated secretory phenotype increase in the blood of
elderly individuals or individuals with age-associated diseases or with infections. Although …