Serum GFAP levels correlate with astrocyte reactivity, post-mortem brain atrophy and neurofibrillary tangles

P Sánchez-Juan, E Valeriano-Lorenzo… - Brain, 2024 - academic.oup.com
Glial fibrillary acidic protein (GFAP), a proxy of astrocyte reactivity, has been proposed as
biomarker of Alzheimer's disease. However, there is limited information about the correlation …

[HTML][HTML] GFAP as a potential biomarker for Alzheimer's disease: a systematic review and meta-analysis

KY Kim, KY Shin, KA Chang - Cells, 2023 - mdpi.com
Blood biomarkers have been considered tools for the diagnosis, prognosis, and monitoring
of Alzheimer's disease (AD). Although amyloid-β peptide (Aβ) and tau are primarily blood …

Plasma GFAP is an early marker of amyloid-β but not tau pathology in Alzheimer's disease

JB Pereira, S Janelidze, R Smith, N Mattsson-Carlgren… - Brain, 2021 - academic.oup.com
Although recent clinical trials targeting amyloid-β in Alzheimer's disease have shown
promising results, there is increasing evidence suggesting that understanding alternative …

Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: Associations with Aβ‐PET, neurodegeneration, and cognition

P Chatterjee, L Vermunt, BA Gordon… - Alzheimer's & …, 2023 - Wiley Online Library
Background Glial fibrillary acidic protein (GFAP) is a promising candidate blood‐based
biomarker for Alzheimer's disease (AD) diagnosis and prognostication. The timing of its …

Plasma glial fibrillary acidic protein is an early marker of Aβ pathology in Alzheimer's disease

JB Pereira, S Janelidze, R Smith, N Mattsson-Carlgren… - medRxiv, 2021 - medrxiv.org
Although recent clinical trials targeting amyloid-β (Aβ) in Alzheimer's disease (AD) have
shown promising results, there is increasing evidence suggesting that understanding …

Plasma glial fibrillary acidic protein in the Alzheimer disease continuum: relationship to other biomarkers, differential diagnosis, and prediction of clinical progression

XN Shen, SY Huang, M Cui, QH Zhao, Y Guo… - Clinical …, 2023 - academic.oup.com
Background Plasma glial fibrillary acidic protein (GFAP) has emerged as a promising
biomarker in neurological disorders, but further evidence is required in relation to its …

Neuropathological validation of plasma GFAP

AL Benedet, DS Smirnov, NJ Ashton… - Alzheimer's & …, 2022 - Wiley Online Library
Background Glial fibrillary acidic protein (GFAP) is an astrocytic marker that has been
recently associated with fluid and imaging biomarkers of amyloid and tau pathologies in the …

[HTML][HTML] Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer's disease

P Chatterjee, S Pedrini, E Stoops, K Goozee… - Translational …, 2021 - nature.com
Glial fibrillary acidic protein (GFAP), an astrocytic cytoskeletal protein, can be measured in
blood samples, and has been associated with Alzheimer's disease (AD). However, plasma …

[HTML][HTML] Clinical and biological relevance of glial fibrillary acidic protein in Alzheimer's disease

Z Yang, K Sreenivasan, EN Toledano Strom… - Alzheimer's Research & …, 2023 - Springer
Introduction There is a tremendous need for identifying reliable blood-based biomarkers for
Alzheimer's disease (AD) that are tied to the biological ATN (amyloid, tau and …

[HTML][HTML] Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive …

C Cicognola, S Janelidze, J Hertze… - Alzheimer's research & …, 2021 - Springer
Introduction Plasma glial fibrillary acidic protein (GFAP) is a marker of astroglial activation
and astrocytosis. We assessed the ability of plasma GFAP to detect Alzheimer's disease …