Sequence-specific RNA-binding proteins (RBPs) bind to pre-mRNA to control alternative
splicing, but it is not yet possible to read the'splicing code'that dictates splicing regulation on …

In violation of the'one gene, one polypeptide'rule, alternative splicing allows individual
genes to produce multiple protein isoforms—thereby playing a central part in generating …

Alternative splicing of mRNA precursors provides an important means of genetic control and
is a crucial step in the expression of most genes. Alternative splicing markedly affects human …

Alternative splicing of pre-messenger RNA transcripts enables the generation of multiple
protein isoforms from the same gene locus, providing a major source of protein diversity in …

Alternative splicing is a highly regulated process that greatly increases the proteome
diversity and plays an important role in cellular differentiation and disease. Interactions …

Alternative splicing is now recognized as a ubiquitous mechanism for controlling gene
expression in a tissue-specific manner. A growing body of work from the past few years has …

▪ Abstract Alternative splicing of pre-mRNAs is a powerful and versatile regulatory
mechanism that can effect quantitative control of gene expression and functional …

Alternative pre-mRNA splicing, the differential inclusion or exclusion of portions of a nascent
transcript into the final protein-coding mRNA, is widely recognized to be a ubiquitous …

The generation of protein coding mRNAs from pre-mRNA is a fundamental biological
process that is required for gene expression. Alternative pre-mRNA splicing is responsible …

Alternative splicing is a widespread means of increasing protein diversity and regulating
gene expression in eukaryotes. Much progress has been made in understanding the …