Parkinson's disease (PD) is the second most prevalent neurodegenerative disease of the
central nervous system (CNS), which affects mostly older adults. In recent years, the …

Background Parkinson's disease (PD) is a prevalent neurological disease in the elderly with
increasing morbidity and mortality. Despite enormous efforts, rapid and accurate diagnosis …

Objective The pathogenesis of Parkinson's disease (PD) involves complex interactions
between environmental and genetic factors. Metabolomics can shed light on alterations in …

Parkinson's disease is the second most common neurodegenerative disease. In the vast
majority of cases the origin is not genetic and the cause is not well understood, although …

Parkinson's disease (PD) shows high heterogeneity with regard to the underlying molecular
pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging …

Proteomics and metabolomics are two emerging fields that hold promise to shine light on the
molecular mechanisms causing neurodegenerative diseases. Research in this area may …

The lack of knowledge about the onset and progression of Parkinson's disease (PD)
hampers its early diagnosis and treatment. Metabolomics might shed light on the PD imprint …

Biomarker research in Parkinson's disease (PD) has long been dominated by measuring
dopamine metabolites or alpha-synuclein in cerebrospinal fluid. However, these markers do …

Neurons in the mature human central nervous system (CNS) perform a wide range of motor,
sensory, regulatory, behavioral, and cognitive functions. Such diverse functional output …

Although great effort has been put forth to uncover the complex molecular mechanisms
exploited in the pathogenesis of Parkinson's disease, a satisfactory explanation remains to …