Depression is a severe mental health problem that affects people regardless of social status
or education, is associated with changes in mood and behavior, and can result in a suicide …

Major depressive disorder is one of the most prevalent mental health disorders. Monoamine-
based antidepressants were the first drugs developed to treat major depressive disorder …

Major depressive disorder (MDD) is a common and serious illness of our times, associated
with monoamine deficiency in the brain. Moreover, increased levels of cortisol, possibly …

During the past 10 years our knowledge about the pharmacotherapy of depression has
been consolidated, and a variety of very interesting new compounds launched onto the …

Despite the important advances in the understanding of the pathophysiology of MDD, a
large proportion of depressed patients do not respond well to currently available …

Since the introduction of tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors
(MAOIs) in mid-1950's, treatment of depression has been dominated by monoamine …

The first effective antidepressants, monoamine oxidase inhibitors and tricyclic
antidepressants, were identified 50 years ago, largely through serendipity. These …

Introduction Deficiencies in standard of care antidepressants are driving novel drug
discovery. A new age of antidepressant medications has emerged with the introduction of …

Depression is the most common psychiatric illness affecting numerous people world-wide.
The currently available antidepressant treatment presents low response and remission …

The goal of this review is to provide a provocative discussion of the status of antidepressant
treatments in the next century. The first part of the review evaluates the progress (or lack of …