Aberrant activation of TGF-β signaling plays a pivotal role in cancer metastasis and
progression. However, molecular mechanisms underlying the dysregulation of TGF-β …

Perturbations in transforming growth factor-β (TGF-β) signaling can lead to a plethora of
diseases, including cancer. Mutations and posttranslational modifications (PTMs) of the …

The downregulation of tight junction protein CLDN6 promotes breast cancer cell migration
and invasion; however, the exact mechanism underlying CLDN6 downregulation remains …

The malignant transformation in several types of cancer, including lung cancer, results in a
loss of growth inhibition by transforming growth factor-β (TGF-β). Here, we show that SMAD6 …

Non-small cell lung cancer (NSCLC) is a fatal disease, and its metastatic process is poorly
understood. Although aberrant methylation is involved in tumor progression, the …

Transforming growth factor-β (TGF-β) signaling pathways are well-recognized for their role
in proliferation and epithelial–mesenchymal transition (EMT) of cancer cells, but much less …

SMAD3 plays a central role in cancer metastasis, and its hyperactivation is linked to poor
cancer outcomes. Thus, it is critical to understand the upstream signaling pathways that …

Abstract AlkB homolog 5 (ALKBH5) has been revealed as a key RNA N6‐methyladenosine
(m6A) demethylase that is implicated in development and diseases. However, the function of …

Objective YTH domain family 2 (YTHDF2) is an important N6-methyladenosine (m6A)
reader, but its role in lung adenocarcinoma remains elusive. This study assessed its function …

Non-small cell lung cancer (NSCLC) is the major cause of cancer mortality worldwide.
Though multidisciplinary therapies have been widely used for NSCLC, its overall prognosis …