Peptide inhibitors of viral membrane fusion

N Düzgüneş, K Konopka - Medical Research Archives, 2020 - esmed.org
Lipid-enveloped viruses, including HIV-1 and SARS-CoV-2, infect their host cells by fusion
either directly with the plasma membrane or with the endosome membrane following …

Fusogenic effect of cholesterol prevails over the inhibitory effect of a peptide-based membrane fusion inhibitor

GP Pattnaik, H Chakraborty - Langmuir, 2021 - ACS Publications
Membrane fusion is the primary step in the entry of enveloped viruses into the host cell.
Membrane composition modulates the membrane fusion by changing the organization …

[HTML][HTML] Fusion peptide induced modification of membrane organization and dynamics: Implications in developing fusion inhibitors

S Mishra, MS Panda, H Chakraborty - Chemical Physics Impact, 2023 - Elsevier
An essential step in the entrance of enveloped viruses such as coronaviruses, the human
immunodeficiency virus, and influenza is membrane fusion. A unique class of glycoprotein …

Combining 25-hydroxycholesterol with an HIV fusion inhibitor peptide: interaction with biomembrane model systems and human blood cells

B Gomes, G Sanna, S Madeddu… - ACS infectious …, 2019 - ACS Publications
The fusion between the viral and the target cell membrane is a crucial step in the life cycle of
enveloped viruses. The blocking of this process is a well-known therapeutic approach that …

HIV fusion inhibitor peptide T-1249 is able to insert or adsorb to lipidic bilayers. Putative correlation with improved efficiency

AS Veiga, NC Santos, LMS Loura… - Journal of the …, 2004 - ACS Publications
T-1249 is a HIV fusion inhibitor peptide under clinical trials. Its interaction with biological
membrane models (large unilamellar vesicles) was studied using fluorescence …

Inhibition of viral membrane fusion by peptides and approaches to peptide design

N Düzgüneş, N Fernandez-Fuentes, K Konopka - Pathogens, 2021 - mdpi.com
Fusion of lipid-enveloped viruses with the cellular plasma membrane or the endosome
membrane is mediated by viral envelope proteins that undergo large conformational …

What studies of fusion peptides tell us about viral envelope glycoprotein-mediated membrane fusion

SR Durell, I Martin, JM Ruysschaert, Y Shai… - Molecular membrane …, 1997 - Taylor & Francis
This review describes the numerous and innovative methods used to study the structure and
function of viral fusion peptides. The systems studied include both intact fusion proteins and …

Peptide-based inhibitors of the HIV envelope protein and other class I viral fusion proteins

I Steffen, S Pohlmann - Current pharmaceutical design, 2010 - ingentaconnect.com
Viruses need to deliver their genomic information into the host cell lumen to establish
productive infection. Enveloped viruses accomplish this task by fusing their membrane with …

Viral fusion peptides: a tool set to disrupt and connect biological membranes

LK Tamm, X Han - Bioscience reports, 2000 - Springer
The structure and function of viral fusion peptides are reviewed. The fusion peptides of
influenza virus hemagglutinin and human immunodeficiency virus are used as paradigms …

Demonstrating the C‐terminal boundary of the HIV 1 fusion conformation in a dynamic ongoing fusion process and implication for fusion inhibition

Y Wexler‐Cohen, Y Shai - The FASEB journal, 2007 - Wiley Online Library
The core complex is a structure involved in the fusion mechanism of many viruses, as well
as in intracellular vesicle fusion. A powerful approach for studying the dynamic stages of HIV …